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首页> 外文期刊>Innovations: technology and techniques in cardiothoracic and vascular surgery >A Simple Porcine Model of Inducible Sustained Atrial Fibrillation.
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A Simple Porcine Model of Inducible Sustained Atrial Fibrillation.

机译：诱导型持续性心房颤动的简单猪模型。

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The surgical management of atrial fibrillation (AF) is an evolving field with a history of testing various lesion sets and ablation technologies. Previous animal models of AF require a chronic intervention to make AF reliably inducible. Our objective was to create an acute, reliable, and reproducible porcine model of sustained AF. To accomplish this, 21 adult domestic pigs underwent median sternotomy. Methods to induce AF were then performed sequentially: manual stimulation, rapid pacing (200 beats per minute), and then rapid pacing of 8 beats with a cycle length of 300 milliseconds, followed by an extra stimulus at decreasing cycle lengths. If AF was not induced, burst pacing was performed at a cycle length of 90 milliseconds for 30 seconds. If AF was still not induced, intravenous neostigmine was administered, and the process was repeated. Atrial fibrillation was considered sustained after 1 minute. Attempts at AF induction were successful in 18 (86%) of 21. Atrial fibrillation was induced during manual stimulation in four (19%), during rapid pacing in five (24%), during burst pacing in five (24%), and after the administration of neostigmine in four (19%). Mean (SD) duration of AF was 3.6 (2.6) minutes. Of the 18, 14 (78%) reverted to sinus rhythm spontaneously and 4 (22%) required an antiarrhythmic. This technique of inducing AF can easily be used to evaluate new technologies and lesion sets without the need for creating a chronic animal model.
机译：心房颤动（AF）的外科治疗是一个不断发展的领域，具有测试各种病变组和消融技术的历史。以前的房颤动物模型需要长期干预才能可靠地诱发房颤。我们的目标是建立一个持续性房颤的急性，可靠和可复制的猪模型。为此，对21只成年家猪进行了正中胸骨切开术。然后依次进行诱发AF的方法：手动刺激，快速起搏（每分钟200次），然后以300毫秒的循环时间快速起搏8次，然后以减小的循环长度进行额外刺激。如果未诱发房颤，则以90毫秒的周期长度进行突发起搏30秒。如果仍未诱发房颤，则静脉内注射新斯的明，并重复该过程。 1分钟后认为房颤持续。在21例中有18例（86％）成功诱发了房颤，在手动刺激中有4例（19％），在快速起搏中有5例（24％），在突发起搏中有5例（24％）诱发了房颤。在新斯的明的给药后有四个（19％）。 AF的平均（SD）持续时间为3.6（2.6）分钟。 18例中有14例（78％）自发恢复窦性心律，4例（22％）需要抗心律失常。这种诱发房颤的技术可轻松用于评估新技术和病变集，而无需创建慢性动物模型。

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