Organometallic ruthenium complexes with thiosemicarbazone ligands: Synthesis, structure and cytotoxicity of [(η~6-p-cymene)Ru(NS)Cl]~+ (NS = 9-anthraldehyde thiosemicarbazones)

Floyd A. Beckford; Gabriel Leblanc; Jeffrey Thessing

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Organometallic ruthenium complexes with thiosemicarbazone ligands: Synthesis, structure and cytotoxicity of [(η~6-p-cymene)Ru(NS)Cl]~+ (NS = 9-anthraldehyde thiosemicarbazones)

机译：硫代半碳杂zone配体的有机金属钌配合物：[（η〜6-对-cymene）Ru（NS）Cl]〜+（NS = 9-蒽甲醛硫代半碳唑酮）的合成，结构和细胞毒性

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A series of half-sandwich arene ruthenium complexes containing bidentate thiosemicarbazone ligands have been synthesized and their biological activity investigated. The compounds have the general formula [(6-p-cymene)Ru(R-ATSC)Cl]X (ATSC = 9-anthraldehyde thiosemicarbazone and R = H, CH3 and C6H5). The crystal structure of [(6-p-cymene) Ru(MeATSC)Cl]Cl have been determined and represents the first structurally characterized arene-ruthenium half-sandwich complex with a thiosemicarbazone ligand. The complexes show good cytotoxic profiles against MCF-7 and MDA-MB-231 (breast adenocarcinoma) as well as HCT 116 and HT-29 (colorectal carcinoma) cell lines.

机译：已合成了一系列含有双齿硫代半碳酰胺配体的半三明治芳烃钌配合物，并对其生物学活性进行了研究。所述化合物具有通式[（6-对-异丙基）Ru（R-ATSC）Cl] X（ATSC ＝ 9-蒽硫代半缩酮，R ＝ H，CH 3和C 6 H 5）。已经确定了[（6-对-cymene）Ru（MeATSC）Cl] Cl的晶体结构，并代表了第一个具有硫代半脲配体的芳烃-钌半三明治复合物。该复合物显示出对MCF-7和MDA-MB-231（乳腺癌）以及HCT 116和HT-29（结肠直肠癌）细胞系的良好细胞毒性。

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《Inorganic Chemistry Communications》 |2009年第11期|共5页
作者
Floyd A. Beckford; Gabriel Leblanc; Jeffrey Thessing;
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正文语种 eng
中图分类无机化学;
关键词
Thiosemicarbazones; Ruthenium-arene complex; DNA interaction; Viscometry; Cytotoxicity; Structure elucidation;

机译：硫代氨基甲酮;钌-芳烃配合物;DNA相互作用;粘度法;细胞毒性;结构解析;

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1. Organometallic ruthenium complexes with thiosemicarbazone ligands: Synthesis, structure and cytotoxicity of [(η~6-p-cymene)Ru(NS)Cl]~+ (NS = 9-anthraldehyde thiosemicarbazones) [J] . Floyd A. Beckford, Gabriel Leblanc, Jeffrey Thessing Inorganic Chemistry Communications . 2009,第11期

机译：硫代半碳杂zone配体的有机金属钌配合物：[（η〜6-对-cymene）Ru（NS）Cl]〜+（NS = 9-蒽甲醛硫代半碳唑酮）的合成，结构和细胞毒性
2. New dinuclear ruthenium arene complexes containing thiosemicarbazone ligands: synthesis, structure and cytotoxic studies [J] . Su Wei, Tang Zhaofeng, Li Peiyuan, Dalton transactions: An international journal of inorganic chemistry . 2016,第48期

机译：新型的含硫半脲配体的双核钌芳烃配合物：合成，结构和细胞毒性研究
3. [J] . Jebiti Haribabu, Gopal Sabapathi, Manoharan Muthu Tamizh, Organometallics . 2018,第8期

机译：<！[CDATA [水溶性单℃（η 6 - p -cymene）配合物含有吲哚硫代蓟司障子鸟：合成，DFT建模，生物分子相互作用和< i>通过细胞凋亡体外 - 抗癌活性]]>
4. Synthesis and Reactions of Ruthenium Complexes Bearing Diphosphinidenecyclobutene Ligands (DPCB-Y) [C] . Akito Hayashi, Takahiko Yoshitomi, Masaaki Okazaki Symposium on Organometallic Chemistry . 2007

机译：含二磷苯丁丁烯配体的钌配合物的合成与反应（DPCB-Y）
5. Structure-activity relationships of ruthenium(II) polypyridyl complexes with redox-active intercalating ligands: Correlation between redox activity, DNA cleavage capability and cytotoxicity. [D] . Narh, Eugenia Soyo. 2015

机译：钌（II）聚吡啶基配合物与氧化还原活性的嵌入配体的结构活性关系：氧化还原活性，DNA裂解能力和细胞毒性之间的相关性。
6. Organometallic ruthenium complexes with thiosemicarbazone ligands: Synthesis structure and cytotoxicity of (η6-p-cymene)Ru(NS)Cl+ (NS = 9-anthraldehyde thiosemicarbazones) [O] . Floyd A. Beckford, Gabriel Leblanc, Jeffrey Thessing, -1

机译：有机金属钌络合物与配体缩氨基硫脲的合成结构和细胞毒性（η6 - 对 - 伞花烃）钌（Ns）CL +（Ns = 9-anthraldehyde缩氨基硫脲）
7. Organometallic ruthenium complexes with thiosemicarbazone ligands: Synthesis, structure and cytotoxicity of (η6-p-cymene)Ru(NS)Cl+ (NS=9-anthraldehyde thiosemicarbazones) [O] . Floyd A. Beckford, Gabriel Leblanc, Jeffrey Thessing, 2009

机译：有机金属钌配合物用硫代吡吡吡咯配体：（η6-p-cyhyene）ru（ns）cl +（ns = 9-α硫代肾上腺脱氨酸）的合成，结构和细胞毒性）
8. Chemistry of Polynuclear Metal Complexes with Bridging Carbene or Carbyne Ligands. Part 93. Synthesis of Heteropolynuclear Metal Compounds with Chains of Seven to Eleven Metal Atoms; Crystal Structure of (Mo2W3Pt6(Mu3-CMe)3(Mu3-CC6H4Me-4)2(CO)10(PMe2Ph)4(Eta-C5H5)5). [R] . Davies, S. J., Howard, J. A., Musgrove, R. J., 1989

机译：具有桥接卡宾或卡宾配体的多核金属配合物的化学。第93部分。具有7至11个金属原子链的杂多核金属化合物的合成; （mo2W3pt6（mu3-Cme）3（mu3-CC6H4me-4）2（CO）10（pme2ph）4（Eta-C5H5）5）的晶体结构。

Organometallic ruthenium complexes with thiosemicarbazone ligands: Synthesis, structure and cytotoxicity of [(η~6-p-cymene)Ru(NS)Cl]~+ (NS = 9-anthraldehyde thiosemicarbazones)

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