Pybox ligand-promoted copper(I)-catalyzed three-component tandem coupling-annulation of terminal alkynes, amines and ortho-alkynylaryl aldehydes

Min Yu; Ying Wang; Chao-Jun Li

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Pybox ligand-promoted copper(I)-catalyzed three-component tandem coupling-annulation of terminal alkynes, amines and ortho-alkynylaryl aldehydes

机译：Pybox配体促进的铜（I）催化的末端炔烃，胺和邻炔基芳基醛的三组分串联偶联-环化

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Pybox ligand was utilized to promote a highly efficient, one-pot, copper(I)-catalyzed three-component tandem addition and cyclization of ortho-alkynylaryl aldehydes, primary amines, and terminal alkynes. Dihydroisoquinoline derivatives 2 were achieved with excellent to moderate yields. In some examples, water was found as an additive to activate the reaction with or without Pybox ligand. Compared with the reported methods, in which imine had to be pre-prepared and purified, the novel process provides a greener choice.

机译：Pybox配体用于促进高效，一锅，铜（I）催化的三组分串联加成反应和邻炔基芳基醛，伯胺和末端炔烃的环化反应。以优异至中等的产率获得了二氢异喹啉衍生物2。在一些实例中，发现水作为添加物以在有或没有Pybox配体的情况下活化反应。与已报道的必须预先制备和纯化亚胺的方法相比，该新方法提供了更绿色的选择。

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《Inorganic Chemistry Communications》 |2009年第11期|共4页
作者
Min Yu; Ying Wang; Chao-Jun Li;
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正文语种 eng
中图分类无机化学;
关键词
Dihydroisoquinoline; Pybox ligand; Three-component tandem addition and; cyclization;

机译：二氢异喹啉;Pybox配体;三组分串联加成;环化;

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1. Pybox ligand-promoted copper(I)-catalyzed three-component tandem coupling-annulation of terminal alkynes, amines and ortho-alkynylaryl aldehydes [J] . Min Yu, Ying Wang, Chao-Jun Li Inorganic Chemistry Communications . 2009,第11期

机译：Pybox配体促进的铜（I）催化的末端炔烃，胺和邻炔基芳基醛的三组分串联偶联-环化
2. Pybox ligand-promoted copper(I)-catalyzed three-component tandem coupling-annulation of terminal alkynes, amines and ortho-alkynylaryl aldehydes [J] . Min Yu, Ying Wang, Chao-Jun Li Inorganic Chemistry Communications . 2009,第11期

机译：Pybox配体促进的铜（I）催化的末端炔烃，胺和邻炔基芳基醛的三组分串联偶联-环化
3. Pybox ligand-promoted copper(I)-catalyzed three-component tandem coupling-annulation of terminal alkynes, amines and ortho-alkynylaryl aldehydes [J] . Min Yu, Ying Wang, Chao-Jun Li Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2009,第49期

机译：Pybox配体促进的铜（I）催化的末端炔烃，胺和邻炔基芳基醛的三组分串联偶联-环化
4. Enantioselective Addition of Terminal Alkynes to Aldehydes Catalyzed by a Copper(I)-TRAP Complex [C] . Yohsuke Asano, Hajime Ito, Masaya Sawamura Symposium on Organometallic Chemistry . 2007

机译：将终端炔烃对铜（I） - 综合复合物催化的末端炔烃加入醛
5. Part I. Asymmetric organocatalysis: (1) Direct enantioselective organocatalytic hydroxymethylation of aldehydes catalyzed by alpha,alpha-diphenylprolinol trimethylsilyl ether: Application in the formal synthesis of (-)-Rasfonin; (2) Synthesis of a novel bicyclic secondary amine organocatalyst: Application to the direct enantioselective organocatalytic hydroxymethylation of aldehydes. Part II. Asymmetric synthesis of bicyclic analogues of the anti-osteoporotic drug risedronate. [D] . Miller, John Robert. 2010

机译：第一部分，不对称有机催化：（1）α，α-二苯基脯氨醇三甲基甲硅烷基醚催化的醛的直接对映选择性有机催化羟甲基化：在（-）-Rasfonin的正式合成中的应用；（2）新型双环仲胺有机催化剂的合成：应用于醛的直接对映选择性有机催化羟甲基化。第二部分抗骨质疏松药物Risedronate的双环类似物的不对称合成。
6. Vicinal Diboronates in High Enantiomeric Purity through Tandem Site-Selective NHC–Cu-Catalyzed Boron-Copper Additions to Terminal Alkynes [O] . Yunmi Lee, Hwanjong Jang, Amir H. Hoveyda -1

机译：邻Diboronates高对映体纯度通过汇接站点选择性NHC铜催化硼铜添置端炔
7. Three-component coupling of aldehydes, amines and alkynes catalyzed by oxidized copper nanoparticles on titania [O] . Albaladejo Maricó, María José, Alonso Valdés, Francisco, Moglie, Yanina, 2012

机译：二氧化钛上氧化铜纳米粒子催化醛，胺和炔烃的三组分偶联

Pybox ligand-promoted copper(I)-catalyzed three-component tandem coupling-annulation of terminal alkynes, amines and ortho-alkynylaryl aldehydes

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