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Homonuclear dinickel complexes:structural mimics for the dinickel subsite of the A-cluster of acetyl-CoA synthase

机译:同核双镍配合物:乙酰辅酶A合酶A簇的双镍亚位的结构模拟

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摘要

[Ni(ema)(mu-S,S')Ni(dppp)] (1) and [Ni(ema)(mu-S,S')Ni(dppe)] (2) have been prepared as synthetic structural analogues of the Ni-Ni subsite of the A-cluster of the enzyme acetyl-CoA synthase by reaction of [Ni(ema)]~(2-),H_4ema is N,N'-ethylenebis(2-mercaptoac-etamide),with [NiCl_2(diphos)],diphos is l,2-bis(diphenylphosphino)propane (dppp) or l,2-bis(diphenylphosphino)ethane (dppe).A similar reaction with l,2-bis(diethylphosphino)ethane did not give the dinuclear product but the trinuclear complex {Ni(ema)(mu-S,S')}2] (3).Complexes 1 and 3 have been crystallographically characterised.
机译:[Ni(ema)(mu-S,S')Ni(dppp)](1)和[Ni(ema)(mu-S,S')Ni(dppe)](2)已制备为合成结构类似物[Ni(ema)]〜(2-),H_4ema反应生成的乙酰辅酶A合酶A簇的Ni-Ni亚位为N,N'-亚乙基双(2-巯基乙酰胺), [NiCl_2(diphos)],diphos是1,2-双(二苯基膦基)丙烷(dppp)或1,2-双(二苯基膦基)乙烷(dppe)。与1,2-双(二乙基膦基)乙烷的类似反应没有给出了双核产物,但三核复合物{Ni(ema)(mu-S,S')} 2](3)。配合物1和3已在晶体学上进行了表征。

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