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首页> 外文期刊>British Journal of Haematology >Prospects for primary stroke prevention in children with sickle cell anaemia
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Prospects for primary stroke prevention in children with sickle cell anaemia

机译：镰状细胞性贫血儿童原发性卒中的预防前景

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摘要

This review will focus on the strengths and limitations associated with the current standard of care for primary prevention of ischaemic strokes in children with sickle cell anaemia (SCA) - transcranial Doppler ultrasound (TCD) screening followed by regular blood transfusion therapy when TCD measurement is above a threshold defined by a randomized clinical trial (RCT). The theoretical basis for potential alternative strategies for primary prevention of neurological injury in SCA is also discussed. These strategies will include, but will not be limited to: immunizations to prevent bacterial infections, particularly in low income countries; management of elevated blood pressure; and targeted strategies to increase baseline haemoglobin levels with therapies such as hyroxycarbamide or potentially definitive haematopoietic stem cell transplant.
机译：这篇综述将侧重于与镰状细胞性贫血（SCA）患儿缺血性卒中一级预防的现行护理标准相关的优势和局限性-经颅多普勒超声（TCD）筛查，当TCD测量值高于上述水平时进行常规输血治疗由随机临床试验（RCT）定义的阈值。还讨论了在SCA中一级预防神经损伤的潜在替代策略的理论基础。这些策略将包括但不限于：预防细菌感染的免疫接种，特别是在低收入国家;血压升高的管理;采取针对性的策略，例如使用羟尿嘧啶或潜在的确定性造血干细胞移植来增加基线血红蛋白水平。

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