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首页> 外文期刊>British Journal of Haematology >Low-dose acyclovir prophylaxis for bortezomib-induced herpes zoster in multiple myeloma patients
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Low-dose acyclovir prophylaxis for bortezomib-induced herpes zoster in multiple myeloma patients

机译:小剂量阿昔洛韦预防硼替佐米引起的多发性骨髓瘤患者带状疱疹

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摘要

Treatment of multiple myeloma (MM) with bortezomib results in the induction of high overall response rates. However, there is evidence of an increased incidence of herpes zoster during bortezomib treatment (Richardson et al, 2005; Kropff et al, 2007; Chanan-Khan et al, 2008; San Miguel et al, 2008). The occurence of herpes zoster is mostly managable, although it might delay or interrupt proper chemotherapy or even become dose-limiting. On the other hand, herpetic infections are easily preventable. Long term administration of acyclovir to all patients receiving bortezomib in clinical trials lead to eradication of this unfavourable condition (Mateos et al, 2006). Some recent papers have reported successful prevention, even with lower doses of acyclovir (Pour et al, 2009; Vickrey et al, 2009; Kim et al, 2011; Swaika et al, 2012). To date, however, there has not been a consensus on an appropriate prophylactic dose of acyclovir.
机译:硼替佐米治疗多发性骨髓瘤(MM)导致诱导高总体缓解率。但是,有证据表明在硼替佐米治疗期间带状疱疹的发生率增加(Richardson等,2005; Kropff等,2007; Channa-Khan等,2008; San Miguel等,2008)。带状疱疹的发生大部分是可控制的,尽管它可能会延迟或中断适当的化学疗法,甚至会限制剂量。另一方面,疱疹感染很容易预防。在临床试验中,长期向所有接受硼替佐米治疗的患者长期服用阿昔洛韦可消除这种不利状况(Mateos等,2006)。最近的一些论文报道了成功的预防,即使使用较低剂量的阿昔洛韦也是如此(Pour等,2009; Vickrey等,2009; Kim等,2011; Swaika等,2012)。然而,迄今为止,关于适当剂量的阿昔洛韦的预防剂量尚未达成共识。

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