Management of autoimmune diseases after haematopoietic stem cell transplantation

HolbroA.; AbinunM.; DaikelerT.

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Management of autoimmune diseases after haematopoietic stem cell transplantation

机译：造血干细胞移植后自身免疫疾病的管理

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Autologous and allogeneic haematopoietic stem cell transplantation (HSCT) is an option for the treatment of malignant and non-malignant diseases, including the severe autoimmune diseases. Intriguingly, the 'new' autoimmunity developing after transplantation is a constantly recognized phenomenon, which has to be differentiated from original disease relapse, toxicity, infection and graft-versus-host disease. The reported autoimmune diseases occurring in this setting are mainly antibody-associated and organ-specific, with scarce evidence in support for specific treatment options. This review focuses on current concepts on the pathogenesis, the available data on incidence, risk factors, manifestations and treatment of post-HSCT autoimmune diseases.

机译：自体和异体造血干细胞移植（HSCT）是治疗恶性和非恶性疾病（包括严重的自身免疫性疾病）的一种选择。有趣的是，移植后发展出的“新”自身免疫是一个一直公认的现象，必须与原始疾病的复发，毒性，感染和移植物抗宿主病区分开。据报道，在这种情况下发生的自身免疫性疾病主要是抗体相关和器官特异性的，缺乏支持特定治疗选择的证据。这篇综述着重于当前的发病机理，HSCT后自身免疫性疾病的发病率，危险因素，表现和治疗的可用数据。

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《British Journal of Haematology》 |2012年第3期|共10页
作者
HolbroA.; AbinunM.; DaikelerT.;
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正文语种 eng
中图分类血液及淋巴系疾病;
关键词
Allogeneic; Autoimmune disease; Cord blood; Management; Transplantation;

机译：同种异体;自身免疫性疾病;脐血;处理;移植;

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1. Autoimmune cytopenias (AIC) following allogeneic haematopoietic stem cell transplant for acquired aplastic anaemia: a joint study of the Autoimmune Diseases and Severe Aplastic Anaemia Working Parties (ADWP/SAAWP) of the European Society for Blood and Marrow Transplantation (EBMT) [J] . Miller Paul D. E., Snowden John A., De Latour Regis Peffault, Bone marrow transplantation . 2020,第2期

机译：同种异体造血干细胞移植后自身免疫性细胞分开（AIC）用于获得的血栓性贫血：欧洲血液和骨髓移植社会自身免疫性疾病和严重血栓性贫血工作缔约方（ADWP / SAAWP）的联合研究（EBMT）
2. General information for patients and carers considering haematopoietic stem cell transplantation (HSCT) for severe autoimmune diseases (ADs): A position statement from the EBMT Autoimmune Diseases Working Party (ADWP), the EBMT Nurses Group, the EBMT Patient, Family and Donor Committee and the Joint Accreditation Committee of ISCT and EBMT (JACIE) [J] . Jessop Helen, Farge Dominique, Saccardi Riccardo, Bone marrow transplantation . 2019,第7期

机译：考虑呕血的患者和护士患者的一般信息，用于严重的自身免疫疾病（ADS）：EBMT自身免疫疾病工作党（ADWP），EBMT患者，家庭和捐助者委员会的招聘人员疫苗（ADWP）和 ISCT和EBMT联合认证委员会（Jacie）
3. Evaluating the clinical effectiveness of autologous haematopoietic stem cell transplantation versus disease-modifying therapy in multiple sclerosis using a matching-adjusted indirect comparison: an exploratory study from the Autoimmune Diseases Working Party (ADWP) of the European Society of Bone and Marrow Transplantation (EBMT) [J] . Bone marrow transplantation . 2020,第7期

机译：评价使用匹配调整的间接比较的多发性硬化症中自体造血干细胞移植与疾病修饰治疗的临床效果：欧洲骨骼和骨髓移植社会的自身免疫疾病工作党（ADWP）的探索性研究（EBMT）
4. Intense immunosuppression and stem cell transplantation in severe autoimmune diseases [C] . Lisukov, I.A. . 2000

机译：严重自身免疫疾病中的强免疫抑制和干细胞移植
5. Haematopoietic stem cell transplantation for thalassaemia major. [D] . Li, Chi Kong. 2002

机译：重型地中海贫血的造血干细胞移植。
6. General information for patients and carers considering haematopoietic stem cell transplantation (HSCT) for severe autoimmune diseases (ADs): A position statement from the EBMT Autoimmune Diseases Working Party (ADWP) the EBMT Nurses Group the EBMT Patient Family and Donor Committee and the Joint Accreditation Committee of ISCT and EBMT (JACIE) [O] . Helen Jessop, Dominique Farge, Riccardo Saccardi, -1

机译：正在考虑对严重自身免疫性疾病（ADs）进行造血干细胞移植（HSCT）的患者和护理人员的一般信息：EBMT自身免疫性疾病工作组（ADWP）EBMT护士组EBMT患者家庭和捐赠者委员会以及ISCT和EBMT联合认证委员会（JACIE）
7. Autoimmune cytopenias (AIC) following allogeneic haematopoietic stem cell transplant for acquired aplastic anaemia: a joint study of the Autoimmune Diseases and Severe Aplastic Anaemia Working Parties (ADWP/SAAWP) of the European Society for Blood and Marrow Transplantation (EBMT) [O] . Paul D. E. Miller, John A. Snowden, Regis Peffault De Latour, 2019

机译：同种异体造血干细胞移植后自身免疫性细胞分开（AIC）用于获得的血栓性贫血：欧洲血液和骨髓移植社会自身免疫性疾病和严重血栓性贫血工作缔约方（ADWP / SAAWP）的联合研究（EBMT）

Management of autoimmune diseases after haematopoietic stem cell transplantation

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