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首页> 外文期刊>British Journal of Haematology >Chronic lymphocytic leukaemia responsive to vitamin D administration.
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Chronic lymphocytic leukaemia responsive to vitamin D administration.

机译:对维生素D给药有反应的慢性淋巴细胞性白血病。

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摘要

Since the 1980s, the extra-osseous effects of vitamin D (VD) have attracted growing attention, mainly related to immuno-modulation and tumour inhibition. Many normal tissues, as well as some tumour cells (colon, pancreas, breast, prostate, leukaemias, etc.), display nuclear receptors specific for VD (VDR). Several epidemiological studies have suggested an inverse association between serum 25-hydroxyvitaminD [25(OH)_2 D_3] concentration, and the incidence of several solid cancers (Luong & Nguyen, 2009). More recently, Shanafelt et al (2011) reported, for the first time, that vitamin D (VD) insufficiency is associated with lower survival in chronic lymphocytic leukaemia (CLL) patients. Nevertheless, the therapeutic efficiency of VD in CLL has not been reported to date.
机译:自1980年代以来,维生素D(VD)的骨外作用引起了越来越多的关注,主要与免疫调节和肿瘤抑制有关。许多正常组织以及一些肿瘤细胞(结肠,胰腺,乳腺,前列腺,白血病等)都显示出对VD(VDR)有特异性的核受体。几项流行病学研究表明,血清25-羟基维生素D [25(OH)_2 D_3]浓度与几种实体癌的发生率呈负相关(Luong&Nguyen,2009)。 Shanafelt等人(2011年)最近首次报道,维生素D(VD)功能不全与慢性淋巴细胞性白血病(CLL)患者的较低生存率相关。然而,迄今为止尚未报道VD在CLL中的治疗效率。

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