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首页> 外文期刊>British Journal of Haematology >Asparaginase-associated pancreatitis in children
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Asparaginase-associated pancreatitis in children

机译：小儿天冬酰胺酶相关性胰腺炎

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摘要

l-asparaginase has been an element in the treatment for acute lymphoblastic leukaemia (ALL) and non-Hodgkin lymphoma since the late 1960s and remains an essential component of their combination chemotherapy. Among the major toxicities associated with l-asparaginase therapy are pancreatitis, allergic reactions, thrombotic events, hepatotoxicity and hyperlipidaemia. Acute pancreatitis is one of the most common reasons for stopping treatment with l-asparaginase. Short-term complications of asparaginase-associated pancreatitis include development of pseudocysts and pancreatic necrosis. Long-term complications include chronic pancreatitis and diabetes. The pathophysiology of asparaginase-associated pancreatitis remains to be uncovered. Individual clinical and genetic risk factors have been identified, but they are only weak predictors of pancreatitis. This review explores the definition, possible risk factors, treatment and complications of asparaginase-associated pancreatitis.
机译：自1960年代后期以来，l-天冬酰胺酶一直是治疗急性淋巴细胞白血病（ALL）和非霍奇金淋巴瘤的要素，并且仍然是其联合化疗的重要组成部分。与l-天冬酰胺酶疗法有关的主要毒性包括胰腺炎，过敏反应，血栓形成事件，肝毒性和高脂血症。急性胰腺炎是停止使用l-天冬酰胺酶治疗的最常见原因之一。与天冬酰胺酶相关的胰腺炎的短期并发症包括假性囊肿的发展和胰腺坏死。长期并发症包括慢性胰腺炎和糖尿病。与天冬酰胺酶相关的胰腺炎的病理生理学仍有待发现。已经确定了个别的临床和遗传危险因素，但它们只是胰腺炎的弱预测指标。这篇综述探讨了天冬酰胺酶相关性胰腺炎的定义，可能的危险因素，治疗方法和并发症。

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