• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Influenza and other respiratory viruses. >Cross-reactive antibody response to pandemic H1N1 2009 in mainland China
【24h】

Cross-reactive antibody response to pandemic H1N1 2009 in mainland China

机译：中国大陆对2009年H1N1大流行的交叉反应抗体反应

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: We measured the cross-reactive antibody-response to pandemic H1N1 2009 in children and adults before and after vaccination with 2007-2008, 2008-2009 influenza season vaccines as part of the rapid public health response to the emergence of pH1N1 and to provide evidence for pH1N1 vaccination policy development in mainland China. Materials and methods: Archived serum specimens from previous vaccine studies were detected by Hemagglutination inhibition assay. Results: Limited cross-reactive antibody response to pHlNl had been detected among participants of all age groups before and after they had been vaccinated with 2007-2008, 2008-2009 influenza seasonal vaccines. Vaccination with seasonal influenza viruses resulted in limited seroconversion to pHlNl in all age groups, compared with 59-94% of seroconversion to seasonal influenza viruses. But similar to recent studies, a peak of cross-reactive antibody response to pHlNl was observed in 23% and 39% of participants born from 1915 to 1925 before and after vaccination. Conclusions: In order to protect our populations in China, our study strongly suggests vaccination with pH1N1 is required in all age groups and that older populations born before 1925 may be associated with a lower infection rate of pH1N1.
机译：背景：我们测量了2007-2008年，2008-2009年流感季节疫苗接种前后儿童和成人对大流行H1N1 2009的交叉反应抗体反应，作为对pH1N1出现的快速公共卫生反应的一部分，并提供中国大陆制定pH1N1疫苗接种政策的证据。材料和方法：通过血凝抑制试验检测先前疫苗研究中存档的血清标本。结果：在接种2007-2008、2008-2009流感季节性疫苗之前和之后，所有年龄组的参与者均检测到对pH1N1的交叉反应抗体反应有限。在所有年龄组中，季节性流感病毒的疫苗接种导致有限的血清转化为pH1N1，相比之下，季节性流感病毒的转化率为59-94％。但是与最近的研究相似，在1915年至1925年出生的疫苗接种前后，分别有23％和39％的参与者对pH1N1产生了交叉反应性抗体反应的峰值。结论：为了保护中国的人口，我们的研究强烈建议在所有年龄段都需要接种pH1N1疫苗，并且1925年之前出生的老年人口可能与pH1N1的较低感染率有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号