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Universal vaccination: is this premature with current vaccine approaches?

机译：通用疫苗接种：目前的疫苗方法还为时过早吗？

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Intuitively, continual immunisation of everyone against influenza continuously throughout their lifetime would be desirable, and may even lead to a better community outcome than predicted based on the 30-70% efficacy of the vaccine through the establishment of herd immunity. However, this scenario may, at times, render the community particularly vulnerable to influenza, especially if we confine ourselves to the vaccines that are typically in use today. Vaccines that exert their effects solely through induction of highly specific neutralising antibodies are beneficial, but their universal use may leave a population more susceptible in a scenario of vaccine mismatch or if a new subtype of virus emerges. Cross-protective responses, such as those invoked and continually boosted by natural infection, are probably the reason why most individuals experience severe influenza on only a few occasions during their lifetime.Similar concerns to these have been voiced by Rim-melzwaan's group in the context of the introduction of widespread vaccination of children. Vaccination of healthy children from 6 months of age against seasonal influenza has now been recommended in several countries including the USA and in Europe. Children are particularly at risk from seasonal influenza and also form a considerable reservoir of the virus, allowing spread to other sectors of the community, such as the vulnerable elderly. Clearly vaccination of this target group with antigenically well-matched vaccines has significant impact on disease burden.
机译：凭直觉，每个人在其一生中持续进行抗流感的连续免疫将是理想的，甚至可能比基于通过建立群免疫的疫苗的30-70％功效所预测的结果更好的社区结果。但是，这种情况有时可能会使社区特别容易感染流感，特别是如果我们将自己局限于今天通常使用的疫苗中。仅通过诱导高度特异性的中和抗体发挥作用的疫苗是有益的，但在疫苗错配或出现新的病毒亚型的情况下，它们的普遍使用可能会使人群更易感染。交叉保护反应（例如自然感染引起并不断增强的反应）可能是大多数人在一生中仅几次经历严重流感的原因.Rim-melzwaan小组在此背景下也表达了类似的担忧对儿童进行广泛的疫苗接种。现在已建议在多个国家（包括美国和欧洲）对6个月以上的健康儿童接种季节性流感疫苗。儿童特别容易受到季节性流感的威胁，并形成大量的病毒库，从而可以传播到社区的其他部门，例如脆弱的老年人。显然，用抗原匹配的疫苗对该目标人群进行疫苗接种会对疾病负担产生重大影响。

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