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首页> 外文期刊>Brain research. Brain research protocols >Neonatal prefrontal cortex lesion using CO2 laser technique.
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Neonatal prefrontal cortex lesion using CO2 laser technique.

机译：使用CO2激光技术的新生儿前额叶皮层病变。

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Prefrontal cortex (PFC) is a large area of the brain and its neonatal lesion with ibotenic or kainic acid is used to study the early abnormalities in neurodevelopment that lead to behavioral changes linked to schizophrenia. However, these exitotoxic drugs produce a large and asymmetric damage in the PFC. We produced the bilateral lesions of the dorsal part of the PFC of neonatal Sprague-Dawley rats (postnatal day 7, P7) at the anteroposterior +2.5 mm and mediolateral +/-0.4 coordinates by the new laser technique that employ the confined radiation of the CO(2) laser in the pulsed mode. The laser was used because its coherent radiation can be focused in a very small spot and as small as of several tens of micrometers in diameters. The CO(2) laser radiation is strongly absorbed by water that is present in any soft tissue. Thereafter, the configuration of the heated zone and, consequently, that of the lesion does not depend on the morphological non-homogeneity of particular structures. We obtained the symmetric, conical in shape and small-size bilateral lesions of the PFC. The size of the lesion depended on the beam spot-size and could be as small as several dozens of micrometers in diameter. Our data suggests that the laser technique will be used for the anatomical-functional studies of the PFC in the brain.
机译：前额叶皮层（PFC）是大脑的一个很大区域，其新生儿病灶中含有ibotenic或海藻酸，用于研究神经发育的早期异常，该异常导致与精神分裂症相关的行为改变。但是，这些排毒药物会在PFC中产生较大且不对称的损伤。我们采用新的激光技术，利用新生鼠的局限放射线，在新生鼠的前后+2.5 mm和中外侧+/- 0.4坐标处产生了新生Sprague-Dawley大鼠（出生后第7天，P7）PFC背侧的双侧病变。脉冲模式的CO（2）激光器。之所以使用激光，是因为其相干辐射可以聚焦在一个非常小的点上，并且直径可以小到几十微米。 CO（2）激光辐射被任何软组织中存在的水强烈吸收。此后，加热区的构造以及因此病变的构造不取决于特定结构的形态非均质性。我们获得了PFC的对称，圆锥形和小尺寸双侧病变。病变的大小取决于束斑的大小，直径可能小至几十微米。我们的数据表明，激光技术将用于大脑中PFC的解剖功能研究。

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