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首页> 外文期刊>Injury >Effect of administration of platelet-rich plasma in early phases of distraction osteogenesis: An experimental study in an ovine femur model
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Effect of administration of platelet-rich plasma in early phases of distraction osteogenesis: An experimental study in an ovine femur model

机译：富含血小板血浆在牵张成骨早期阶段的作用：在绵羊股骨模型中的实验研究

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Background: It has been suggested that platelet-rich plasma (PRP) might enhance bone formation. The aim of this study was to quantify the effect of PRP administered in the early phases of distraction osteogenesis in an ovine femur model. Methods: Twenty sheep aged 4 months underwent osteotomy of the femoral diaphysis followed by distraction osteogenesis. The sheep were divided into two groups of 10. One group received three injections of PRP on days 0, 10, and 20 of the procedure (PRP group) and the other received no additional treatment (control group). The results were evaluated by computed tomography (CT) and histology on completion of distraction osteogenesis (day 40). CT evaluation included measurement of the callus and bone density. Femur size was also measured proximally and distally. Histological evaluation was used to quantify osteoblasts, osteoclasts, vascular lumens, and trabecular maturity by zones and to calculate trabecular bone, fibrous tissue, and cartilage ratios. Results: Radiological and histological evaluation of the regenerate bone showed no significant differences between the PRP group and the control group for any of the variables analysed. The only significant difference detected was a wider femur (increased diaphyseal thickness) at the proximal and distal levels in the PRP group. Conclusion: We found no radiological or histological evidence that the administration of PRP in the early phases of distraction osteogenesis enhances bone formation.
机译：背景：有人提出富血小板血浆（PRP）可能会增强骨形成。这项研究的目的是量化在绵羊股骨模型中牵张成骨早期阶段施用PRP的效果。方法：对20只4个月大的绵羊进行股骨干physi骨截骨术，然后进行成骨术。将绵羊分为两组，每组10只。一组在手术的第0、10和20天接受三次PRP注射（PRP组），另一组不接受其他治疗（对照组）。在完成牵张成骨（第40天）时，通过计算机断层扫描（CT）和组织学对结果进行评估。 CT评估包括骨the和骨密度的测量。股骨的大小也测量近端和远端。组织学评估用于按区域量化成骨细胞，破骨细胞，血管腔和小梁成熟度，并计算小梁骨，纤维组织和软骨比率。结果：再生骨的放射学和组织学评估显示，在分析的任何变量中，PRP组和对照组之间没有显着差异。在PRP组中，检测到的唯一显着差异是股骨近端和远端的股骨更宽（骨干厚度增加）。结论：我们没有发现放射学或组织学证据表明在牵张成骨的早期阶段施用PRP可以增强骨形成。

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