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Management of venous thromboembolism - controversies and the future

机译:静脉血栓栓塞的治疗-争议和未来

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摘要

Despite the availability of comprehensive evidence-based guidelines there are difficult and controversial areas in the management of venous thromboembolism. Institutions and even countries disagree on the importance of calf vein thrombosis, with some rigorously detecting and treating it and others deliberately not looking for it. The need to treat proximal deep vein thrombosis and pulmonary embolism is accepted but which patients with an unprovoked first event should have long-term anticoagulation has become a difficult clinical decision. We are uncertain how to reduce the incidence of post-thrombotic syndrome seen in a substantial number of patients. How hard to look for an undiagnosed underlying cancer has become a contentious issue particularly in the United Kingdom following the recent publication of a guideline from the National Institute for Health and Clinical Excellence. Whilst we are wrestling with these dilemmas we are entering an era of new anticoagulants and have to solve the logistical problems of introducing them into clinical practice despite cost pressures. These issues will be explored in this review.
机译:尽管有全面的循证指南,但在静脉血栓栓塞的管理方面仍存在困难和有争议的领域。机构甚至国家不同意小腿静脉血栓形成的重要性,其中一些严格检测和治疗,而另一些则故意不寻找它。接受治疗近端深静脉血栓形成和肺栓塞的必要性已被接受,但是哪些患者因无故的首发事件应进行长期抗凝治疗已成为一项困难的临床决策。我们不确定如何减少大量患者的血栓形成后综合征的发生率。在国家健康与临床卓越研究所最近发​​布指南之后,如何寻找难以诊断的潜在癌症已成为一个有争议的问题,尤其是在英国。在努力解决这些难题的同时,我们正在进入一种新的抗凝剂时代,尽管存在成本压力,但必须解决将其引入临床实践的后勤问题。这些问题将在这篇评论中探讨。

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