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Artificial nerve tubes and their application for repair of peripheral nerve injury: an update of current concepts

机译：人工神经管及其在周围神经损伤修复中的应用：最新概念

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摘要

Over the last 20 years, an increasing number of research articles have reported on the use of artificial nerve tubes to repair nerve defects. The development of an artificial nerve tube as an alternative to autogenous nerve grafting is currently a focus of interest for peripheral nerve repair. The clinical employment of tubes as an alternative to autogenous nerve grafts is mainly justified by the limited availability of donor tissue for nerve autografts and the related morbidity. Numerous studies indicate that short-distance defects in humans can be successfully treated by implantation of artificial nerve guides. This review provides a brief overview of various preclinical and clinical trials conducted to evaluate the utility of artificial nerve tubes for the regeneration of peripheral nerves. This review is also intended to help update hand surgeons on the rapid advances in tubulization techniques, and to provide them with indications of the various directions toward which future research can proceed. Future studies need to provide us with as much comparative information as possible on the effectiveness of different tubulization techniques, in order to guide the surgeon in choosing the best indications for their optimal clinical employment. Future progress in implant development can be expected from interdisciplinary approaches involving both materials and life sciences, leading to advances in neuro-tissue engineering that will be needed to effectively treat larger nerve defects.
机译：在过去的20年中，越来越多的研究文章报道了使用人工神经管修复神经缺损。替代自体神经移植的人工神经管的开发目前是周围神经修复的关注焦点。管子作为自体神经移植物的替代品在临床上的使用主要是由于供体组织用于神经自体移植物的可用性有限以及相关的发病率是有道理的。大量研究表明，通过植入人工神经导管可以成功治疗人的短距离缺陷。这篇综述简要概述了各种临床前和临床试验，以评估人造神经管在周围神经再生中的效用。这篇综述还旨在帮助手外科医师了解输卵管技术的快速发展，并为他们提供未来研究可朝着的各个方向的指示。未来的研究需要向我们提供有关不同输卵管技巧有效性的尽可能多的比较信息，以指导外科医生为他们的最佳临床工作选择最佳适应症。涉及材料和生命科学的跨学科方法可以预期植入物开发的未来进展，这将导致神经组织工程学的进步，这将是有效治疗较大神经缺损所必需的。

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