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首页> 外文期刊>British Journal of Haematology >Pegylated liposomal doxorubicin: An efficient treatment in patients with Hodgkin lymphoma relapsing after high dose therapy and stem cell transplation
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Pegylated liposomal doxorubicin: An efficient treatment in patients with Hodgkin lymphoma relapsing after high dose therapy and stem cell transplation

机译:聚乙二醇脂质体阿霉素:高剂量治疗和干细胞移植后霍奇金淋巴瘤复发的有效治疗方法

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摘要

Relapsed and refractory Hodgkin lymphoma (HL) patients receive salvage chemotherapy and high-dose chemotherapy (HDT), with autologous stem-cell transplantation (ASCT) as a standard of treatment (Schmitz et al, 2002). Some patients still relapse again and, at tune of relapse, most patients can no longer receive doxorubicin due to the probable cardiotox-icity of its cumulative dose. A pegylated-liposomal formulation of doxorubicin (PLD) has reduced cardiac toxicity compared to non-liposomal doxorubicin (Gabizon, 2001).
机译:复发和难治性霍奇金淋巴瘤(HL)患者接受挽救性化疗和大剂量化疗(HDT),并将自体干细胞移植(ASCT)作为治疗标准(Schmitz等,2002)。一些患者仍然再次复发,并且在复发时,由于其累积剂量可能的心脏毒性,大多数患者不再接受阿霉素。与非脂质体阿霉素相比,阿霉素(PEGD)的聚乙二醇脂质体制剂可降低心脏毒性(Gabizon,2001)。

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