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首页> 外文期刊>Brain research. Brain research protocols >Hypothalamic neuroactivity in specific processes and central regulation of body temperature and water intake.
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Hypothalamic neuroactivity in specific processes and central regulation of body temperature and water intake.

机译：下丘脑神经活动在特定过程中以及对体温和摄水量的集中调节。

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The method described was designed to elucidate the role of a particular neuronal system or specific nucleus in the central nervous system (CNS) in controlling physiological and biological functions. The neurochemical aspects of the CNS regulatory mechanism and related networks remain to be further investigated. There is little information available about the relationship between neuroactivity in the specific brain nuclei and physiological or biological responses in mammals. An adequate analysis of this relationship provides valuable insight to clarify which nucleus and what types of neurons are truly involved in the excitation of physiological events and its regulation. In the present study, we used microdialysis for stimulation of the anterior hypothalamus (AH) and simultaneous analysis of cholinergic activity, and we investigated c-Fos-like immunoreactivity (Fos-IR) in the brain in the same animal following microdialysis. The nuclear protein c-Fos, the product of c-fos oncogene, has been used as a marker of neuronal activity at the cellular level in the brain. Various physiological and pharmacological stimuli have been shown to induce Fos-IR in specific neuronal populations located in various regions of the brain. However, there are few studies investigating the responses produced by c-Fos expression in specific regions in same animals. We showed the involvement of hypothalamic cholinergic mechanisms in the thermoregulatory and water regulatory processes using the above procedures.
机译：所描述的方法旨在阐明中枢神经系统（CNS）中特定神经系统或特定核在控制生理和生物学功能中的作用。中枢神经系统调节机制和相关网络的神经化学方面有待进一步研究。关于特定脑核中的神经活动与哺乳动物的生理或生物学反应之间的关系的信息很少。对这种关系的充分分析提供了宝贵的见解，以阐明哪些核和哪些类型的神经元真正参与了生理事件及其调节的激发。在本研究中，我们使用微透析刺激下丘脑前部（AH）并同时分析胆碱能活性，并且我们在微透析后调查了同一只动物的大脑中c-Fos样免疫反应性（Fos-IR）。 c-fos癌基因的产物核蛋白c-Fos已被用作大脑细胞水平神经元活性的标志物。已经显示出各种生理和药理刺激在位于大脑各个区域的特定神经元群体中诱导Fos-IR。但是，很少有研究调查c-Fos在同一动物的特定区域表达所产生的反应。我们显示了使用上述程序在温度调节和水调节过程中下丘脑胆碱能机制的参与。

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