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首页> 外文期刊>Interdisciplinary perspectives on infectious diseases >Incidence and Clinical Predictors of Ocular Candidiasis in Patients with Candida Fungemia
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Incidence and Clinical Predictors of Ocular Candidiasis in Patients with Candida Fungemia

机译：念珠菌性真菌病患者眼念珠菌病的发病率和临床预测

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Purpose. The aim of this study is to determine the incidence and the predictors of ocular candidiasis among patient with Candida fungemia. Methods. We retrospectively reviewed the charts of all patients diagnosed with candidemia at the University of Kansas Medical Center during February 2000-March 2010. Data regarding patients' demographics, clinical characteristics, laboratory results, and ophthalmology examination findings were collected. Results. A total of 283 patients with candidemia were enrolled. The mean age (± standard deviation) was 55 ± 18 years; 66% were male. The most commonly isolated Candida species were C. albicans (54%), C. parapsilosis (20%), C. glabrata (13%), and C. tropicalis (8%). Only 144 (51%) patients were evaluated by ophthalmology; however, the proportion of patients who were formally evaluated by an ophthalmologist increased during the study period (9%in 2000 up to 73%in 2010; P < 0.0001). Evidence of ocular candidiasis was present in 18 (12.5%) patients. Visual symptoms were reported by 5 of 18 (28%) patients. In multivariable analysis, no predictors of ocular candidiasis were identified. Conclusions. The incidence of ocular candidiasis among patients with fungemia remains elevated. Most patients are asymptomatic and therefore all patients with candidemia should undergo fundoscopic examination to rule out ocular involvement.
机译：目的。这项研究的目的是确定念珠菌性真菌病患者眼念珠菌病的发生率和预测因素。方法。我们回顾性分析了2000年2月至2010年3月在堪萨斯大学医学中心诊断为念珠菌血症的所有患者的病历。收集了有关患者的人口统计学，临床特征，实验室结果和眼科检查结果的数据。结果。共有283名念珠菌血症患者入组。平均年龄（±标准差）为55±18岁; 66％是男性。最常见的念珠菌是白色念珠菌（54％），副念珠菌（20％），光滑念珠菌（13％）和热带念珠菌（8％）。只有144名（51％）患者接受了眼科评估;然而，在研究期间，由眼科医生正式评估的患者比例有所增加（2000年为9％，2010年为73％; P <0.0001）。 18名（12.5％）患者存在眼念珠菌病的证据。 18位患者中有5位（28％）报告了视觉症状。在多变量分析中，未发现眼念珠菌病的预测因子。结论真菌病患者眼念珠菌病的发生率仍然很高。大多数患者无症状，因此所有念珠菌血症患者均应接受眼底镜检查以排除眼部受累。

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