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首页> 外文期刊>Interdisciplinary perspectives on infectious diseases >A Multicenter Study of Beta-Lactamase Resistant Escherichia coli and Klebsiella pneumoniae Reveals High Level Chromosome Mediated Extended Spectrum beta Lactamase Resistance in Ogun State, Nigeria
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A Multicenter Study of Beta-Lactamase Resistant Escherichia coli and Klebsiella pneumoniae Reveals High Level Chromosome Mediated Extended Spectrum beta Lactamase Resistance in Ogun State, Nigeria

机译：耐β-内酰胺酶的大肠埃希菌和肺炎克雷伯菌的多中心研究揭示了尼日利亚奥贡州高水平染色体介导的广谱β-内酰胺酶耐药性

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As a result of the ever increasing problem of multiresistant bacteria, we instituted a surveillance program with the aim of identifying the basic molecular properties of ESBL in our environment. About 197 isolates of Escherichia coli and Klebsiella pneumoniae were selected and tested for ESBL production and antimicrobial susceptibility. Plasmid profiles were determined and curing ability was tested. ESBL prevalence was 26.4% for all isolates tested, with E. coli having a greater proportion. There was absolute resistance to ampicilin, tetracycline, and co-trimaxole among tested isolates. There was above average susceptibility to the 2nd and 3rd generation cephalosporins. Plasmid profiles of tested isolates ranged from 9 kbp to 26 kbp with average of 14.99 ± 2.3 kbp for E. coli and 20.98 ±1.8 kbp K. pneumoniae, 9.6% of ESBL positive E. coli plasmids were cured, while 3.9% of K. pneumoniae plasmids were cured after treatment. The present study shows an upsurge in ESBL acquisition by gram negative bacteria and evidence of cocirculation of varying subtypes of ESBL with both plasmid transmissible and chromosome encoded subtypes. This calls for universal surveillance and more effort towards molecular epidemiology of this public health treatment.
机译：由于越来越多的多抗性细菌问题，我们制定了一项监视计划，目的是确定环境中ESBL的基本分子特性。选择了大约197株大肠杆菌和肺炎克雷伯菌，并对其ESBL产生和抗菌药敏性进行了测试。确定质粒图谱并测试固化能力。对于所有测试的分离株，ESBL患病率为26.4％，其中大肠杆菌的比例更高。在测试的分离物中，对氨苄青霉素，四环素和三唑类化合物具有绝对抗性。第二代和第三代头孢菌素的敏感性高于平均水平。测试菌株的质粒图谱介于9 kbp至26 kbp之间，大肠杆菌平均为14.99±2.3 kbp，肺炎克雷伯氏菌为20.98±1.8 kbp，治愈了9.6％的ESBL阳性大肠杆菌质粒，而3.9％的K.治疗后治愈肺炎质粒。本研究显示革兰氏阴性细菌获得ESBL的热潮以及ESBL不同亚型与质粒可传播和染色体编码亚型共同循环的证据。这就要求对这种公共卫生治疗进行普遍监测并朝分子流行病学方面加大努力。

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