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首页> 外文期刊>Interdisciplinary perspectives on infectious diseases >Steroids Decrease Prevalence of Positive Tuberculin Skin Test in Rheumatoid Arthritis: Implications on Anti-TNF Therapies
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Steroids Decrease Prevalence of Positive Tuberculin Skin Test in Rheumatoid Arthritis: Implications on Anti-TNF Therapies

机译：类固醇降低类风湿关节炎的结核菌素皮肤试验阳性率：对抗TNF治疗的影响。

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摘要

Tuberculin skin test has been used as an indicator of latent tuberculosis in patients with Rheumatoid Arthritis (RA) before administration of biologicals. Effect of Disease modifying antirheumatic drugs (DMARDs) and steroids on the result of tuberculin skin test (TST) may have important implications in interpretation of results of this test. Objectives. To find the prevalence of positive TST in rheumatoid patients and the effect of standard treatment on the results of TST. Method. In this cross-sectional study two hundred and fifty patients of RA above 18 years of age, classified using 1987 ACR criteria for RA, were enrolled from rheumatology outdoor. Demographics, disease activity, disease duration, and therapy were recorded. All patients underwent TST. Results. Fifty-one (20.4%) patients were found to be tuberculin positive. Tuberculin positivity was not affected by MTX intake but it was significantly low in patients with recent steroid intake as compared to patients who had not taken steroids in last 3 months (3% versus 25%, P = 0.002). Conclusion. Prevalence of tuberculin positivity in patients with RA was found to be low. Results were not affected by methotrexate; however tuberculin skin test results in patients with recent use of steroids are likely to be negative.
机译：施用生物制剂之前，结核菌素皮肤试验已被用作类风湿关节炎（RA）患者潜伏性结核的指标。疾病抗风湿药（DMARDs）和类固醇对结核菌素皮肤试验（TST）结果的影响可能对该试验结果的解释具有重要意义。目标。了解类风湿患者中TST阳性的患病率以及标准治疗对TST结果的影响。方法。在这项横断面研究中，使用室外风湿病学纳入了1987年针对RA的18岁以上RA的250例患者。记录人口统计，疾病活动，疾病持续时间和治疗。所有患者均接受TST。结果。发现51名（20.4％）患者的结核菌素阳性。结核菌素阳性率不受MTX摄入量的影响，但与最近3个月内未服用类固醇的患者相比，近期服用类固醇的患者的结核菌素阳性率显着较低（3％比25％，P = 0.002）。结论。 RA患者的结核菌素阳性率很低。结果不受甲氨蝶呤的影响;然而，近期使用类固醇的患者的结核菌素皮肤测试结果可能为阴性。

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