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Detection of degeneration in rat sciatic nerve by in vivo near infrared spectroscopy.

机译：体内近红外光谱法检测大鼠坐骨神经变性。

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摘要

We have recently developed an optical spectroscopy technique to monitor light scattering changes of the nervous system in vivo. Near infrared (NIR) spectroscopy emphasizes the detection of light scattering properties, which are prominent within the wavelength range of 700 to 850 nm wavelength. The purpose of this study is to test the hypothesis that demyelination and degeneration of the sciatic nerves after nerve injury will lead to a change in light scattering properties and be detected by the NIR technique. Left spinal nerve ligations (L4, L4 and L5, L5) were performed in rats. The scattering properties of the left (ligated) and right (control) sciatic nerve were measured by the NIR reflectance using a bifurcated needle probe at postoperative days 1, 4, 7, and 14. The results show that there was no significant difference among three types of ligation, and neither did the readings between left and right sciatic nerve at postoperative day 1. Significant decreases in light scattering indexes were found between left and right sciatic nerves at postoperative days 4, 7, and 14. It is concluded that our initial hypothesis is proven, suggesting that the NIR technique may have a potential for clinical application in detecting demyelination and degeneration of the nervous system.
机译：我们最近开发了一种光谱技术，以监测体内神经系统的光散射变化。近红外（NIR）光谱法强调对光散射特性的检测，该特性在700至850 nm波长范围内很显着。这项研究的目的是检验以下假设：神经损伤后坐骨神经的脱髓鞘和变性会导致光散射特性发生变化，并可以通过近红外技术进行检测。在大鼠中进行左脊神经结扎（L4，L4和L5，L5）。在术后第1、4、7和14天使用分叉针探针通过NIR反射率测量左（结扎）和右（对照）坐骨神经的散射特性。结果表明，三者之间没有显着差异结扎的类型，术后第1天左右坐骨神经之间的读数也没有。术后第4、7和14天左右坐骨神经之间的光散射指数显着降低。这一假设得到了证实，这表明近红外光谱技术在检测神经系统脱髓鞘和变性方面可能具有临床应用潜力。

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