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首页> 外文期刊>Brain research. Brain research protocols >Eye-wiping test: a sensitive animal model for acute trigeminal pain studies.
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Eye-wiping test: a sensitive animal model for acute trigeminal pain studies.

机译：擦眼测试：用于急性三叉神经痛研究的敏感动物模型。

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The possibility of introducing eye-wiping test as a model of acute pain was examined in rat, and it was compared with the well-known hot plate test. One drop of NaCl 5 M was placed into the animal eye, and the number of eye wipes with the ipsilateral forelimb was counted during 30 s. The withdrawal latency in hot plate test was also examined. Afterward, animals were treated with morphine (1, 2, 4, 6, 8 or 10 mg/kg), imipramine (25 mg/kg), sodium salicylate (250 mg/kg) or saline (i.p). After 30 min, the animals were tested again with eye-wiping and hot plate tests. Our results showed that morphine injection dose dependently decreased the number of eye wipes and increased the response latency to hot plate tests. There was a good correlation between the analgesic effects of morphine on responses to both tests, however, morphine produced more pain relief in eye-wiping test. Imipramine significantly decreased the number of eye wipes and increased the response latency to hot plate test, while sodium salicylate and saline injection did not. It may be concluded that the eye-wiping test can be used as a reliable method in trigeminal pain studies, which is sensitive to opioid and tricyclic antidepressant in rat.
机译：在大鼠中研究了将擦拭试验作为急性疼痛模型的可能性，并将其与众所周知的热板试验进行了比较。将一滴NaCl 5 M放入动物眼，并在30 s内计数同侧前肢的擦拭巾数。还检查了热板测试中的退出潜伏期。之后，用吗啡（1、2、4、6、8或10 mg / kg），丙咪嗪（25 mg / kg），水杨酸钠（250 mg / kg）或盐水（i.p）治疗动物。 30分钟后，再次通过擦拭和热板测试对动物进行测试。我们的结果表明，吗啡注射剂量依赖地减少了擦拭巾的次数，并增加了对热板测试的反应潜伏期。吗啡的镇痛作用对两种测试的反应之间都具有良好的相关性，但是，吗啡在擦眼试验中产生的止痛效果更大。丙咪嗪显着减少了擦拭巾的次数，并增加了对热板测试的反应潜伏期，而水杨酸钠和盐水注射却没有。可以得出结论，擦眼试验可以作为三叉神经痛研究中的一种可靠方法，该方法对大鼠的阿片类药物和三环类抗抑郁药敏感。

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