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首页> 外文期刊>Briefings in functional genomics & proteomics >Rescuing yeast mutants with human genes
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Rescuing yeast mutants with human genes

机译：用人类基因拯救酵母突变体

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摘要

The fission yeast Schizosaccharomyces pombe and the budding yeast Saccharomyces cerevisiae have, in addition to being extensively studied themselves, both been utilized for the last quarter century as experimental systems for the isolation of genes from other organisms. Mutations conferring growth defects in either of the two yeast strains have frequently been complemented by expression of cDNA libraries from heterologous species, often human. Many successful experiments have utilized available yeast mutations to allow successful complementation by a human gene, which can thus be deduced to have the same, or an overlapping function as the mutated yeast gene. However complementation in yeast has also been used with success to study two fields, apoptosis and steroid receptor signalling, which, at first glance, seem to be foreign to the yeast life cycle.
机译：裂变酵母粟酒裂殖酵母和发芽酵母啤酒酵母除了被广泛研究之外，在过去的四分之一世纪中都被用作从其他生物中分离基因的实验系统。来自两个异源物种（通常是人类）的cDNA文库的表达经常补充了在两个酵母菌株中的任何一个中均导致生长缺陷的突变。许多成功的实验已经利用可获得的酵母突变来允许人类基因的成功互补，因此可以推论其与突变酵母基因具有相同或重叠的功能。然而，酵母中的互补作用也已成功用于研究两个领域，即细胞凋亡和类固醇受体信号传导，乍一看似乎与酵母生命周期无关。

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