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首页> 外文期刊>Briefings in functional genomics & proteomics >A comparative view at comprehensive information resources on three-dimensional structures of biological macro-molecules
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A comparative view at comprehensive information resources on three-dimensional structures of biological macro-molecules

机译：综合信息资源对生物大分子三维结构的比较研究

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摘要

The rapidly increasing amount of information on three-dimensional (3D) structures of biological macro-molecules has still an insufficient impact on genome analysis, functional genomics and proteomics as well as on many other fields in biomedicine including disease-related research. There are, however, attempts to make structural data more easily accessible to the bench biologist. As members of the world-wide Protein Data Bank (wwPDB), the RCSB Protein Data Bank (PDB), the Protein Data Bank Japan and the Macromolecular Structure Database are the primary information resources for 3D structures of proteins, nucleic acids, carbohydrates and complexes thereof. In addition, a number of secondary resources have been set up that also provide information on all currently known structures in a relatively comprehensive manner and not focusing on specific features only. They include PDBsum, the OCA browser-database for protein structure/function, the Molecular Modeling Database and the Jena Library of Biological Macromolecules—JenaLib. Both the primary and secondary resources often merge the information in the PDB files with data from other resources and offer additional analysis tools thereby adding value to the original PDB data. Here, we briefly describe these resources from a user's point of view and from a comparative perspective. It is our aim to guide researchers outside the structure biology field in getting the most out of the 3D structure resources.
机译：有关生物大分子的三维（3D）结构的信息迅速增加，对基因组分析，功能基因组学和蛋白质组学以及包括疾病相关研究在内的生物医学许多其他领域的影响仍然不足。但是，尝试使基础生物学家更容易访问结构数据。作为全球蛋白质数据库（wwPDB）的成员，RCSB蛋白质数据库（PDB），日本蛋白质数据库和大分子结构数据库是蛋白质，核酸，碳水化合物和复合物3D结构的主要信息资源。其。另外，已经建立了许多辅助资源，这些辅助资源还以相对全面的方式提供了所有当前已知结构的信息，而不仅仅是关注特定的特征。它们包括PDBsum，用于蛋白质结构/功能的OCA浏览器数据库，分子建模数据库和生物大分子的耶拿图书馆（JenaLib）。主资源和辅助资源都经常将PDB文件中的信息与其他资源中的数据合并，并提供其他分析工具，从而为原始PDB数据增加价值。在这里，我们从用户的角度和比较的角度简要描述了这些资源。我们的目的是引导结构生物学领域以外的研究人员充分利用3D结构资源。

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