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首页> 外文期刊>Briefings in functional genomics & proteomics >Transposon tools hopping in vertebrates
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Transposon tools hopping in vertebrates

机译:转座子工具在脊椎动物中跳跃

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摘要

In the past decade, tools derived from DNA transposons have made major contributions to vertebrkte genetic studies from gene delivery to gene discovery Multiple, highly complementary systems have been developed, and many more are in the pipeline. Judging which DNA transposon element will work the best in diverse uses from zebrafish, genetic manipulation to human gene therapy is currently a complex task, We have summarized the major transposon vector systems active in vertebrates, comparing and contrasting known critical biochemical and in vivo properties, for future tool design and new genetic applications.
机译:在过去的十年中,从DNA转座子衍生的工具为从基因传递到基因发现的椎体遗传研究做出了重要贡献。已经开发了多个高度互补的系统,并且还有更多的系统正在开发中。判断哪种DNA转座子元件在斑马鱼,基因操作到人类基因治疗等各种用途中效果最佳,目前是一项复杂的工作,我们总结了活跃在脊椎动物中的主要转座子载体系统,比较并对比了已知的关键生化和体内特性,用于将来的工具设计和新的遗传应用。

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