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首页> 外文期刊>Briefings in functional genomics & proteomics >The prediction of protein subcellular localization from sequence: a shortcut to functional genome annotation
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The prediction of protein subcellular localization from sequence: a shortcut to functional genome annotation

机译：从序列预测蛋白质亚细胞定位：功能基因组注释的捷径

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摘要

Automated sequence annotation is a major goal of post-genomic era with hundreds of genomes in the databases, from both prokaryotes and eukaryotes. While the number of fully sequenced chromosomes from microbial organisms exponentially increased in the last decade above 600, presently we know the whole DNA content of only 25 eukaryotic organisms, including Homo sapiens. However, the process of genome annotation is far from being completed. This is particularly relevant in eukaryotes, whose cells contain several subcellular compartments, or organelles, enclosed by membranes, where different relevant functions are performed. Translocation across the membrane into the organelles is a highly regulated and complex cellular process. Indeed different proteins and/or protein isoforms, originated from genes by alternative splicing, may be conveyed to different cell compartments, depending on their specific role in the cell. During recent years the prediction of subcellular localization (SL) by computational means has been an active research area. Several methods are presently available based on different notions and addressing different aspects of SL. This review provides a short overview of the most well performing methods described in the literature, highlighting their predictive capabilities and different applications.
机译：自动序列注释是后基因组时代的一个主要目标，数据库中有数百个来自原核生物和真核生物的基因组。在过去的十年中，尽管来自微生物的完全测序的染色体数量呈指数增长，超过600条，但目前我们知道只有25个真核生物（包括智人）的全部DNA含量。但是，基因组注释的过程远未完成。这在真核生物中尤为重要，在真核生物中，它们的细胞包含被膜包围的多个亚细胞区室或细胞器，在其中执行不同的相关功能。跨膜进入细胞器的转运是高度调节和复杂的细胞过程。实际上，取决于它们在细胞中的特定作用，可以通过替代剪接源自基因的不同蛋白质和/或蛋白质同工型可以被输送至不同的细胞区室。近年来，通过计算手段对亚细胞定位（SL）的预测一直是活跃的研究领域。当前，基于不同的概念并针对SL的不同方面，有几种方法可用。这篇综述简要介绍了文献中描述的最有效的方法，重点介绍了它们的预测能力和不同的应用。

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