Studying gene function in Caenorhabditis elegans using RNA-mediated interference

Eleanor M. Maine

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Studying gene function in Caenorhabditis elegans using RNA-mediated interference

机译：RNA介导的干扰素研究秀丽隐杆线虫的基因功能

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The RNA interference (RNAi) method for targeted gene silencing is widely used in Caenorhabditis elegans for large-scale functional genomic studies, analysis of limited gene sets and detailed analysis of individual gene function. The application of RNAi has identified genes that participate in various aspects of development, physiology and cell biology. In addition, RNAi has been used to identify interacting genes and to study functionally redundant genes. This review discusses the various applications of RNAi in C. elegans, focusing particularly on the analysis of developmental processes.

机译：用于靶向基因沉默的RNA干扰（RNAi）方法已广泛用于秀丽隐杆线虫，用于大规模功能基因组研究，有限基因集的分析以及单个基因功能的详细分析。 RNAi的应用已鉴定出参与发育，生理学和细胞生物学各个方面的基因。另外，RNAi已被用于鉴定相互作用的基因并研究功能上冗余的基因。这篇评论讨论了RNAi在秀丽隐杆线虫中的各种应用，特别是对发育过程的分析。

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《Briefings in functional genomics & proteomics》 |2008年第3期|共11页
作者
Eleanor M. Maine;
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正文语种 eng
中图分类分子生物学;
关键词
Caenorhabditis elegans; RNA; functional genomics; gene networks; gene interaction;

机译：秀丽隐杆线虫;RNA;功能基因组学;基因网络;基因相互作用;

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专利

1. Studying gene function in Caenorhabditis elegans using RNA-mediated interference [J] . Eleanor M. Maine Briefings in functional genomics & proteomics . 2008,第3期

机译：RNA介导的干扰素研究秀丽隐杆线虫的基因功能
2. Functional analysis of the single calmodulin gene in the nematode Caenorhabditis elegans by RNA interference and 4-D microscopy [J] . Karabinos A, Bussing I, Schulze E, European Journal of Cell Biology: Journal of Deutsche Gesellschaft fur Elektronenmikroskopie: Journal of Deutsche Gesellschaft fur Zellbiologie . 2003,第11期

机译：RNA干扰和4-D显微镜对线虫秀丽隐杆线虫中单个钙调蛋白基因的功能分析
3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans [J] . Yuru Zhang, Xiaoju Zou, Yihong Ding, BMC Genomics . 2013,第1期

机译：秀丽隐杆线虫脂质代谢基因的比较基因组学和功能研究
4. Functional post-translational proteomics approach to study the role of N-glycans in the development of Caenorhabditis elegans [C] . Harry Schachter, Shihao Chen, Wenli Zhang, Biochemical Society Symposium . 2002

机译：功能性后翻译蛋白质组学方法研究N-Glycans在Caenorhabditis elegans发育中的作用
5. A systematic study of expression and function of Caenorhabditis elegans genes encoding P-type ATPases in subfamily IV, the group of putative transbilayer amphipath transporters. [D] . Lyssenko, Nicholas N. 2007

机译：系统地研究线虫秀丽隐杆线虫基因在亚家族IV（假定的跨双层两亲性转运蛋白）中的表达和功能。
6. RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans [O] . Mary K. Montgomery, SiQun Xu, Andrew Fire 1998

机译：RNA作为秀丽隐杆线虫双链RNA介导的遗传干扰的目标。
7. RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans [O] . Montgomery, Mary K., Xu, SiQun, Fire, Andrew 1998

机译：RNA作为秀丽隐杆线虫双链RNA介导的遗传干扰的目标。

Studying gene function in Caenorhabditis elegans using RNA-mediated interference

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