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首页> 外文期刊>Intensive care medicine >Risk factors for piperacillin/tazobactam-resistant Escherichia coli in ICU patients: a clinical study.
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Risk factors for piperacillin/tazobactam-resistant Escherichia coli in ICU patients: a clinical study.

机译:ICU患者中对哌拉西林/他唑巴坦耐药的大肠杆菌的危险因素:一项临床研究。

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摘要

OBJECTIVE: To determine risk factors of infections with piperacillin/tazobactam-resistant Escherichia coli in critical care patients. DESIGN: Prospective, consecutive sample survey study. SETTING: Surgical intensive care unit (ICU) in a university hospital. PATIENTS: A consecutive series of 133 patients from whom culture results were positive for E. coli during their ICU stay. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Multivariate logistic regression analysis identified the following significant independent factors associated with the emergence of a piperacillin/tazobactam-resistant Escherichia coli: prior use of amoxicillin (odds ratio, 4.15) and amoxicillin/clavulanate (odds ratio, 3.25). CONCLUSIONS: Treatment with amoxicillin or amoxicillin/clavulanate is a major risk factor for the detection of piperacillin/tazobactam-resistant E. coli in ICU patients.
机译:目的:确定危重病人耐哌拉西林/他唑巴坦的大肠杆菌感染的危险因素。设计:前瞻性,连续样本调查研究。地点:大学医院的外科重症监护室(ICU)。患者:连续133例患者在ICU住院期间培养结果为大肠杆菌阳性。干预措施:无。测量和主要结果:多元逻辑回归分析确定了下列与哌拉西林/他唑巴坦耐药的大肠杆菌的出现相关的重要独立因素:先前使用阿莫西林(比值为4.15)和阿莫西林/克拉维酸(比值为3.25)。结论:阿莫西林或阿莫西林/克拉维酸盐治疗是ICU患者检测哌拉西林/他唑巴坦耐药大肠杆菌的主要危险因素。

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