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首页> 外文期刊>Intensive care medicine >Nontuberculous mycobacteria pulmonary infection in medical intensive care unit: the incidence, patient characteristics, and clinical significance.
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Nontuberculous mycobacteria pulmonary infection in medical intensive care unit: the incidence, patient characteristics, and clinical significance.

机译：重症监护病房中非结核分枝杆菌肺部感染的发生率，患者特征和临床意义。

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BACKGROUND: The clinical significance of nontuberculous mycobacteria (NTM) pulmonary infection in medical intensive care unit (ICU) is still unclear. MATERIALS AND METHODS: We conducted a retrospective study in the medical ICUs of a medical center in Taiwan from January 1999 to June 2007. Patients with NTM isolated from respiratory specimens within 1 month before or during the ICU course were identified. Those who fulfilled the diagnostic criteria of NTM pulmonary infection were identified and compared with patients with NTM colonization and control subjects who were culture-negative for mycobacteria. RESULTS: Among the 5,378 patients admitted to medical ICUs, 2,866 (53.3%) had received mycobacterial culture for respiratory specimens. NTM were isolated from 169 (5.8%) patients. Of them, 47 (27.8%) were considered NTM pulmonary infection. M. avium complex and M. abscessus were the most common pathogens. Within 100 days after ICU admission, significantly more patients with NTM infection died than those with NTM colonization and control subjects (47 vs. 8 vs. 14%, P < 0.001). Twenty-one (49%) patients with NTM pulmonary infection received anti-NTM treatment, with four experiencing adverse effects. Although statistically insignificant, anti-NTM treatment was associated with prolonged survival for those who died in the ICU and shorter ICU stay for those who survived the ICU course. CONCLUSION: Our findings suggest that NTM pulmonary infection seems to associate with higher mortality in medical ICUs. Anti-NTM treatment is probably associated with a better outcome. Therefore, keeping a high suspicion when NTM is isolated and using careful consideration when starting anti-NTM treatment should be emphasized.
机译：背景：重症监护病房（ICU）中非结核分枝杆菌（NTM）肺部感染的临床意义仍不清楚。材料与方法：我们于1999年1月至2007年6月在台湾一家医疗中心的医疗ICU中进行了回顾性研究。确定了在ICU疗程之前或过程中1个月内从呼吸道标本中分离出的NTM患者。确定符合NTM肺部感染诊断标准的患者，并将其与NTM定植的患者和分枝杆菌培养阴性的对照对象进行比较。结果：在5378名接受医疗加护病房的患者中，有2866名（53.3％）接受了呼吸道标本的分枝杆菌培养。从169名（5.8％）患者中分离出NTM。其中47例（27.8％）被认为是NTM肺部感染。鸟分枝杆菌和脓肿分枝杆菌是最常见的病原体。 ICU入院后100天内，NTM感染患者的死亡人数明显多于NTM定植和对照的患者（47％vs. 8％vs. 14％，P <0.001）。 21例（49％）NTM肺部感染患者接受抗NTM治疗，其中4例出现不良反应。尽管在统计学上不显着，但抗NTM治疗与在ICU中死亡的患者的生存期延长和在ICU疗程中生存的患者的ICU住院时间短有关。结论：我们的发现表明，NTM肺部感染似乎与医疗ICU的较高死亡率相关。抗NTM治疗可能会带来更好的结果。因此，在分离NTM时要高度怀疑，在开始抗NTM治疗时应特别注意。

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