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首页> 外文期刊>Briefings in functional genomics & proteomics >Uncharacterized/hypothetical proteins in biomedical ‘omics’ experiments: is novelty being swept under the carpet
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Uncharacterized/hypothetical proteins in biomedical ‘omics’ experiments: is novelty being swept under the carpet

机译：生物医学“组学”实验中未表征/假设的蛋白质：新颖性正席卷地毯

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摘要

Many ‘omics’ studies, gene expression microarray experiments in particular, aim at charting the molecular mechanisms of physiology, disease and drug response. This short review discusses the bias present in many such studies whereas the focus is set on the well understood and established molecular scenarios. The under-reporting rate of ‘hypothetical’ or uncharacterized genes and proteins, differentially regulated in disease context, is assessed here. Reasons for this bias are discussed. Particular examples from the genomics studies on respiratory diseases are presented. This review aims at increasing awareness of the unexplored genomics data and proposes remedies in order to refocus genomics studies on the less-charted territories of the genome, transcriptome and proteome. It is suggested that routine use of function prediction methods in conjunction with omics analyses may allow better interpretation of the data, and facilitate discovery of true novelty.
机译：许多“组学”研究，特别是基因表达微阵列实验，旨在绘制生理，疾病和药物反应的分子机制。这篇简短的评论讨论了许多此类研究中存在的偏见，而重点则放在了众所周知的分子机制上。本文评估了在疾病背景下受到差异调节的“假说”或未表征的基因和蛋白质的漏报率。讨论了这种偏见的原因。介绍了有关呼吸系统疾病的基因组学研究的具体例子。这篇综述旨在提高人们对尚未探索的基因组学数据的认识，并提出了补救措施，以便将基因组学研究的重点重新集中在基因组，转录组和蛋白质组的较少领域。建议将功能预测方法与组学分析结合起来常规使用，可以更好地解释数据，并有助于发现真正的新颖性。

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