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首页> 外文期刊>Briefings in functional genomics & proteomics >Profiling killers; unravelling the pathways of human natural killer cell function
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Profiling killers; unravelling the pathways of human natural killer cell function

机译：分析杀手;揭示人类自然杀伤细胞功能的途径

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摘要

Natural killer (NK) cells are lymphocytes with an innate ability to recognize and kill infected cells and tumour cells. Unlike B and T cells, NK cells do not express an antigen receptor. Instead, NK cells detect changes in the phenotype of the target cell surface; malignant transformation or infection resulting in the loss or gain of particular molecules that are detected by inhibitory or activating receptors on the NK cell surface. The identification and characterization of NK cells and their receptors was made possible by monoclonal antibody technology. The ease with which genes and gene products can now be identified and manipulated has accelerated our understanding of NK cell function. Furthermore, gene and protein profiling studies are beginning to refine our understanding of NK cells, their interactions with other cells and their effector mechanisms. This review illustrates some of the basic features of NK cell biology and highlights the contribution made by post-genomic technology in defining the molecular mechanisms by which NK cells identify and kill susceptible targets.
机译：天然杀伤（NK）细胞是具有天生的识别和杀死受感染细胞和肿瘤细胞能力的淋巴细胞。与B和T细胞不同，NK细胞不表达抗原受体。相反，NK细胞检测靶细胞表面表型的变化。恶性转化或感染会导致特定分子的丢失或增加，这些分子可通过抑制或激活NK细胞表面的受体来检测。 NK细胞及其受体的鉴定和表征通过单克隆抗体技术得以实现。现在可以容易地识别和操纵基因和基因产物，加快了我们对NK细胞功能的了解。此外，基因和蛋白质谱分析研究开始完善我们对NK细胞，它们与其他细胞的相互作用及其效应器机制的了解。这篇综述阐明了NK细胞生物学的一些基本特征，并着重指出了后基因组技术在确定NK细胞识别和杀死易感靶标的分子机制中的贡献。

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