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首页> 外文期刊>Internal medicine journal >Quinine-induced renal failure as a result of rhabdomyolysis, haemolytic uraemic syndrome and disseminated intravascular coagulation.
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Quinine-induced renal failure as a result of rhabdomyolysis, haemolytic uraemic syndrome and disseminated intravascular coagulation.

机译：横纹肌溶解，溶血性尿毒症综合征和弥散性血管内凝血导致奎宁诱发的肾衰竭。

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摘要

This report describes a case of quinine-induced acute renal failure as a result of a combination of haemolytic uraemic syndrome and rhabdomyolysis with disseminated intravascular coagulation. The abrupt onset of symptoms occurred after ingestion of 300 mg of quinine along with atorvastatin. The patient recovered with supportive management, suggesting that plasma exchange may not be necessary in this situation. The possibility of a drug interaction contributing to rhabdomyolysis is raised. The proposed mechanism is through quinine inhibition of the cytochrome P450 isoenzyme 3A4, which may increase systemic levels of atorvastatin by reducing its first-pass metabolism.
机译：该报告描述了一例因溶血性尿毒症综合征和横纹肌溶解症合并弥散性血管内凝血的奎宁诱导的急性肾衰竭病例。摄入300毫克奎宁和阿托伐他汀后，症状突然发作。患者在支持治疗的情况下康复，这表明在这种情况下可能不需要血浆置换。药物相互作用促进横纹肌溶解的可能性增加了。拟议的机制是通过奎宁抑制细胞色素P450同工酶3A4，它可以通过减少其首过代谢来增加阿托伐他汀的全身水平。

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