Severe hypocalcaemia and hypophosphataemia following intravenous iron and denosumab: a novel drug interaction

Smyth B.; Ong S.

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Severe hypocalcaemia and hypophosphataemia following intravenous iron and denosumab: a novel drug interaction

机译：静脉铁剂和地诺单抗后严重低钙血症和低磷血症：一种新型药物相互作用

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We present the case of a 59-year-old woman with chronic kidney disease who suffered severe hypocalcaemia and hypophosphataemia after receiving denosumab and intravenous iron. This potentially life-threatening adverse drug interaction has never been reported before. We propose a mechanism to explain it with reference to the physiological derangements caused by both agents on calcium and phosphate homeostasis.

机译：我们提供了一个患有慢性肾脏疾病的59岁妇女的案例，该妇女在接受denosumab和静脉注射铁后遭受严重的低血钙和低血磷。以前从未报道过这种可能威胁生命的不良药物相互作用。我们提出了一种机制来解释它，这是由两种药剂对钙和磷酸盐稳态引起的生理紊乱引起的。

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《Internal medicine journal》 |2016年第3期|共4页
作者
Smyth B.; Ong S.;
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正文语种 eng
中图分类内科学;
关键词
hypocalcaemia; hypophosphataemia; intravenous iron; iron polymaltose; denosumab; chronic kidney disease;

机译：低血钙症;低磷血症;静脉铁;麦芽糖铁;地塞单抗;慢性肾脏病;

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1. Severe hypocalcaemia and hypophosphataemia following intravenous iron and denosumab: a novel drug interaction [J] . Smyth B., Ong S. Internal medicine journal . 2016,第3期

机译：静脉铁剂和地诺单抗后严重低钙血症和低磷血症：一种新型药物相互作用
2. Denosumab-Induced Severe Hypocalcaemia in Chronic Kidney Disease [J] . Ryan Jalleh, Gopal Basu, Richard Le Leu, Case Reports in Nephrology . 2018,第1期

机译：地诺单抗引起的慢性低钙血症在慢性肾脏疾病中的作用
3. Denosumab and chronic kidney disease: Severe life-threatening hypocalcaemia [J] . Pilar Monge Rafael, ángel Luis Martin de Francisco, Gema Fernández-Fresnedo Nefrologia . 2018,第1期

机译：地诺单抗和慢性肾脏疾病：严重威胁生命的低血钙
4. Mining Severe Drug-Drug Interaction Adverse Events Using Semantic Web Technologies: A Case Study [C] . Guoqian Jiang, Hongfang Liu, Harold R. Solbrig, Pacific-Asia conference on knowledge discovery and data mining;International workshop on biologically inspired data mining techniques;International workshop on data analytics for targeted healthcare;International workshop on big data science and engineering on e-commerce;International workshop on mobile data management, mining and computing on social networks;International workshop on mobile sensing, mining and visualization for human behavior inferences;International workshop on cloud service discovery;International conference on algorithms for large-scale information processing in knowledge discovery;International workshop on scalable dats analytics: thoery and algorithms;nternational workshop on data mining in biomedical informatics and healthcare;International workshop on data mining in social networks;International workshop on pattern mining and application of big data . 2014

机译：使用语义网技术挖掘严重的药物相互作用不良事件：一个案例研究
5. High-resolution NMR spectroscopic analysis of anticancer drugs, DNA and their interactions: 1. Platinum anticancer compounds - DNA interactions. 2. Anthracycline drugs - DNA interactions and modified DNA. [D] . Yang, Danzhou. 1996

机译：抗癌药物，DNA及其相互作用的高分辨率NMR光谱分析：1.铂类抗癌化合物-DNA相互作用。 2.蒽环类药物-DNA相互作用和修饰的DNA。
6. Case Report: Severe hypophosphataemia after intravenous iron administration [O] . Gurpreet Anand, Christoph Schmid 1929

机译：病例报告：静脉铁剂注射后严重低血磷
7. Severe hypophosphataemia after intravenous iron administration [O] . Anand, Gurpreet, Schmid, Christoph 2017

机译：静脉铁剂注射后严重低磷血症

Severe hypocalcaemia and hypophosphataemia following intravenous iron and denosumab: a novel drug interaction

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