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首页> 外文期刊>Internal medicine journal >Use of oral ketamine in a patient with systemic mastocytosis.
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Use of oral ketamine in a patient with systemic mastocytosis.

机译:全身性肥大细胞增多症患者使用口服氯胺酮。

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摘要

A 6 5-year-old woman with metastatic adenocarcinoma of unknown primary with liver metastases presented with severe right upper quadrant abdominal pain. Her significant past history included systemic mastocytosis (with skin and visceral involvement, and paroxysmal symptoms related to mast-cell mediator release (e.g. urticaria, flushing, laryngeal angioedema) triggered by alcohol, heat and certain medications), as well as poorly controlled type II diabetes mellitusHer pain was poorly controlled on regular paracetamol. Because of risk of anaphylaxis, opioids and non-steroidal anti-inflammatories were contraindicated. Subcutaneous ketamine was commenced at 100 mg daily with significant reduction in pain score and no adverse effects.
机译:一名6名5岁女性,患有原发性不明并伴有肝转移的转移性腺癌,伴有严重的右上腹腹痛。她过去的重要历史包括全身性肥大细胞增多症(皮肤和内脏受累,以及由酒精,热和某些药物引起的肥大细胞介质释放相关的阵发性症状(例如荨麻疹,潮红,喉部血管性水肿),以及II型控制不良糖尿病常规扑热息痛治疗后疼痛难以控制。由于存在过敏反应的风险,因此禁止使用阿片类药物和非甾体类抗炎药。每天100 mg皮下注射氯胺酮,疼痛评分明显降低且无不良影响。

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