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首页> 外文期刊>Internal medicine journal >Increasing liver transplantation waiting list mortality: a report from the Australian National Liver Transplantation Unit, Sydney.
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Increasing liver transplantation waiting list mortality: a report from the Australian National Liver Transplantation Unit, Sydney.

机译:肝移植等待名单死亡率的增加:悉尼澳大利亚国家肝移植小组的报告。

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摘要

BACKGROUND: We aimed to describe the demand for liver transplantation (LTx) and patient outcomes on the waiting list at the Australian National Liver Transplantation Unit, Sydney over the last 20 years. METHODS: We performed a retrospective analysis with the data divided into three eras: 1985-1993, 1994-2000 and 2001-2008. RESULTS: The number of patients accepted for LTx increased from 320 to 372 and 548 (P < 0.001) with the number of LTx being performed increasing from 262 to 312 and 452 respectively (P < 0.001). The median adult recipient age increased from 45 to 48 and 52 years (P < 0.001) while it decreased in children from 4 to 2 and 1 years respectively (P = 0.001). In parallel, the deceased donor offers decreased from 1003 to 720 and 717 (P < 0.001). Methods to improve access to donor livers have been used with the use of split livers, extended criteria and non-heart beating donors, resulting in increased acceptance of deceased donor offers by 65% and 115% in the second and third eras when compared with the first era (P < 0.001). However, the adult median waiting time has increased from 23 to 41 and 120 days respectively (P < 0.001). This was associated with increased adult mortality on the waiting list from 23 to 40 and 122 respectively (P < 0.001). CONCLUSIONS: Despite the increasing proportion of donor offers being used, the waiting list mortality is increasing. A solution to this problem is an increase in organ donation to keep pace with the escalating demand for LTx.
机译:背景:我们的目的是在过去的20年中,在悉尼澳大利亚国家肝移植部门的候补名单上描述对肝移植(LTx)的需求和患者预后。方法:我们进行了回顾性分析,数据分为三个时代:1985-1993年,1994-2000年和2001-2008年。结果:接受LTx的患者人数从320增至372和548(P <0.001),而进行LTx的人数分别从262和312增至312和452(P <0.001)。成人接受者的中位年龄从45岁增加到48岁和52岁(P <0.001),而儿童分别从4岁下降到2岁和1岁(P = 0.001)。同时,已故的捐献者的献血量从1003下降到720和717(P <0.001)。与分割肝脏,扩大标准和非心脏跳动的供体一起使用了改善供体肝脏获取的方法,与第二代和第三代相比,已故供体的接受率提高了65%和115%第一个时代(P <0.001)。但是,成年人的中位等待时间分别从23天增加到41天和120天(P <0.001)。这与等待名单上的成人死亡率分别从23增加到40和122(P <0.001)有关。结论:尽管使用捐赠者的比例越来越高,但等待名单的死亡率却在增加。解决此问题的方法是增加器官捐赠,以跟上对LTx不断增长的需求。

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