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首页> 外文期刊>Internal medicine journal >Characterisation and therapeutic manipulation of the gut microbiome in inflammatory bowel disease
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Characterisation and therapeutic manipulation of the gut microbiome in inflammatory bowel disease

机译：炎症性肠病中肠道微生物组的表征和治疗方法

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摘要

Inflammatory bowel diseases are thought to develop as a result of dysregulation of the relationship that exists between the gut microbiota, host genetics and the immune system. The advent of culture-independent techniques has revolutionised the ability to characterise the role of the gut microbiota in health and disease based on the microbiota's genetic make-up. Inflammatory bowel diseases are characterised by dysbiosis which is an imbalance between pro- and anti-inflammatory bacteria and a reduction in bacterial diversity. Emerging data suggest that it is not only the presence of the gut microbiota but the functional activity of the microbiota that appears to play an important role in health and disease. Current strategies to manipulate therapeutically the gut microbiota using dietary modification, prebiotics, probiotics, antibiotics and faecal microbiota transplantation aim to restore the balance to a state of normobiosis. However, the ability of such strategies to correct dysbiosis and thereby achieve therapeutic benefit is yet to be fully characterised.
机译：人们认为，肠道微生物群，宿主遗传学和免疫系统之间关系的失调会导致炎症性肠病的发展。与文化无关的技术的出现彻底改变了根据微生物群的遗传组成来表征肠道微生物群在健康和疾病中的作用的能力。炎症性肠病的特征在于营养不良，这是促炎和消炎细菌之间的不平衡以及细菌多样性的减少。新兴数据表明，不仅肠道菌群的存在，而且菌群的功能活性似乎在健康和疾病中也起着重要作用。当前使用饮食改良，益生元，益生菌，抗生素和粪便微生物群移植治疗肠道菌群的策略旨在将平衡恢复到正常状态。然而，这种策略纠正营养不良并由此获得治疗益处的能力尚未完全表征。

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