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首页> 外文期刊>BioEssays : >Rnd proteins: Multifunctional regulators of the cytoskeleton and cell cycle progression
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Rnd proteins: Multifunctional regulators of the cytoskeleton and cell cycle progression

机译：Rnd蛋白：细胞骨架和细胞周期进程的多功能调节剂

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Rnd3/RhoE has two distinct functions, regulating the actin cytoskeleton and cell proliferation. This might explain why its expression is often altered in cancer and by multiple stimuli during development and disease. Rnd3 together with its relatives Rnd1 and Rnd2 are atypical members of the Rho GTPase family in that they do not hydrolyse GTP. Rnd3 and Rnd1 both antagonise RhoA/ROCK-mediated actomyosin contractility, thereby regulating cell migration, smooth muscle contractility and neurite extension. In addition, Rnd3 has been shown to have a separate role in inhibiting cell cycle progression by reducing translation of cell cycle regulators, including cyclin D1 and Myc. We propose that Rnd3 could act as a tumour suppressor to limit proliferation, but when mutations bypass this activity of Rnd3, it can promote cancer invasion through its effects in the actin cytoskeleton.
机译：Rnd3 / RhoE具有两种不同的功能，调节肌动蛋白的细胞骨架和细胞增殖。这也许可以解释为什么它的表达经常在癌症中以及在发育和疾病期间被多种刺激改变的原因。 Rnd3及其亲属Rnd1和Rnd2是Rho GTPase家族的非典型成员，因为它们不水解GTP。 Rnd3和Rnd1都拮抗RhoA / ROCK介导的肌动球蛋白收缩力，从而调节细胞迁移，平滑肌收缩力和神经突延伸。此外，Rnd3已显示出通过减少细胞周期调节剂（包括细胞周期蛋白D1和Myc）的翻译来抑制细胞周期进程的独立作用。我们提出Rnd3可以作为肿瘤抑制因子来限制增殖，但是当突变绕过Rnd3的这种活性时，它可以通过其对肌动蛋白细胞骨架的影响来促进癌症的侵袭。

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