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Scaling of dorsal-ventral patterning in the Xenopus laevis embryo

机译:非洲爪蟾胚胎的背腹模式的缩放

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摘要

Scaling of pattern with size has been described and studied for over a century, yet its molecular basis is understood in only a few cases. In a recent, elegant study, Inomata and colleagues proposed a new model explaining how bone morphogenic protein (BMP) activity gradient scales with embryo size in the early Xenopus laevis embryo. We discuss their results in conjunction with an alternative model we proposed previously. The expansion-repression mechanism (ExR) provides a conceptual framework unifying both mechanisms. Results of Inomata and colleagues implicate the chordin-stabilizing protein sizzled as the expander molecule enabling scaling, while we attributed this role to the BMP ligand Admp. The two expanders may work in concert, as suggested by the mathematical model of Inomata et al. We discuss approaches for differentiating the contribution of sizzled and Admp to pattern scaling.
机译:已经描述并研究了图案随尺寸的缩放超过一个世纪,但是仅在少数情况下才了解其分子基础。在最近的一项优雅研究中,Inomata及其同事提出了一个新模型,该模型解释了非洲爪蟾早期胚胎中骨形态发生蛋白(BMP)活性梯度如何随胚胎大小而变化。我们将结合先前提出的替代模型讨论其结果。扩展抑制机制(ExR)提供了统一这两种机制的概念框架。 Inomata和他的同事的研究结果表明,增加稳定剂的膨胀蛋白分子使稳定的弦蛋白稳定化,而我们将此作用归因于BMP配体Admp。正如Inomata等人的数学模型所暗示的,这两个扩展器可以协同工作。我们讨论了区分嘶嘶声和Admp对模式缩放的贡献的方法。

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