...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International angiology: A journal of the International Union of Angiology >Influence of the hormonal changes during the normal menstrual cycle in healthy young women on soluble adhesion molecules, plasma homocysteine, free radical markers and lipoprotein fractions.
【24h】

Influence of the hormonal changes during the normal menstrual cycle in healthy young women on soluble adhesion molecules, plasma homocysteine, free radical markers and lipoprotein fractions.

机译：健康年轻女性在正常月经周期中的激素变化对可溶性黏附分子，血浆同型半胱氨酸，自由基标记和脂蛋白组分的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

AIM: Female sex hormones are known to exert a protective role on the vascular endothelial function, but the exact mechanisms of such protection is not known. We aimed to study the possible regulatory role of the female sex hormones changes during the normal menstrual cycle on soluble adhesion molecules E-selectin and ICAM-1, plasma homocyteine, free radical markers and lipoproteins in healthy young women. METHODS: Experimental design: a cross sectional study of healthy female volunteers studied during a single normal menstrual cycle at 3 specific time points. Setting: North Staffordshire Hospitals NHS Trust. Subjects: 20 healthy young menstruating women, aged (mean+/-SEM) 34+/-1 years, with normal menstruation, defined as a menstrual cycle of 21-35 days were studied at 3 time points of the same menstrual cycle. First in the early follicular phase (M-phase), at mid-follicular phase (F-phase), and during the luteal phase (L-phase). Intervention: none. Measurement: serum levels of soluble E-selectin, ICAM-1, plasma homocysteine, vitamin E and malondialdehyde (MDA), as well as lipoprotein fractions were measured at each time points. RESULTS: The mean percentage change for E-selectin between the M-phase and L-phase, F-phase and L-phase were 6% and 4%, respectively, p<0.005, p<0.066. Levels of ICAM-1, vitamin E and malondialdehyde did not vary through the cycle. Homocysteine was not different between M-phase and F-phase (10.39+/-0.68 mmol/l vs 10.33+/-0.65), nor between M-phase and L-phase (10.39+/-0.68 vs 9.77+/-0.75 mmol/l). Although the mean percentage decrease in homocysteine between F- and L-phases was significant (5.36+/-0.53%, p=0.029), the absolute decrease in concentrations was not (p=0.07). There were no cyclical changes in total, LDL, HDL cholesterol, triglycerides, apo A-I, apo B or Lp(a). Using a linear regression model, after correction for age, smoking, body mass index (BMI) and waist/hip ratio (WHR), oestrogen levels were the only predictor of E-selectin during the L-phase p<0.005. There wereno significant correlations between oestrogen with lipids, apolipoproteins or homocysteine. There was an interesting significant univariate correlation between homocysteine with low-density-lipoprotein (LDL) cholesterol and apo B throughout all phases of the cycle, which persisted after correction for the effects of age, BMI, WHR and smoking history. Multiple regression analysis with all these factors showed homocysteine to be a significant predictor of apo B concentration during M (p=0.030) and L-phases (p=0.023) of the cycle and of LDL cholesterol in the M-phase (p=0.033). CONCLUSION: Female sex hormones may have small, though significant modulating role on E-selectin and homocysteine metabolism in healthy premenopausal women. Furthermore, the correlation between homocysteine, LDL and apo B levels suggests that induction of cholesterol synthesis by homocysteine, shown previously in vitro, may be of relevance in vivo.
机译：目的：已知女性性激素对血管内皮功能起保护作用，但这种保护作用的确切机制尚不清楚。我们旨在研究正常月经周期中女性性激素变化对健康年轻女性中可溶性黏附分子E-选择素和ICAM-1，血浆同型红细胞生成素，自由基标记和脂蛋白的调节作用。方法：实验设计：对健康女性志愿者进行的横断面研究，在一个正常的月经周期的3个特定时间点进行。地点：北斯塔福德郡医院NHS信托。受试者：20名健康的年轻经期妇女，年龄（平均+/- SEM）34 +/- 1岁，月经正常，定义为月经周期为21-35天，在同一月经周期的三个时间点进行了研究。首先在卵泡早期（M期），卵泡中期（F期）和黄体期（L期）。干预：无。测量：在每个时间点测量血清可溶性E-选择蛋白，ICAM-1，血浆高半胱氨酸，维生素E和丙二醛（MDA）的水平以及脂蛋白组分。结果：E-选择素在M相和L相，F相和L相之间的平均百分比变化分别为6％和4％，p <0.005，p <0.066。在整个周期中，ICAM-1，维生素E和丙二醛的水平没有变化。同型半胱氨酸在M相和F相之间没有差异（10.39 +/- 0.68 mmol / l vs.10.33 +/- 0.65），在M相和L相之间也没有差异（10.39 +/- 0.68 vs 9.77 +/- 0.75 mmol / l）。尽管在F相和L相之间高半胱氨酸的平均降低百分比很明显（5.36 +/- 0.53％，p = 0.029），但浓度的绝对降低却没有（p = 0.07）。总胆固醇，低密度脂蛋白，高密度脂蛋白胆固醇，甘油三酸酯，载脂蛋白A-1，载脂蛋白B或脂蛋白（a）没有周期性变化。使用线性回归模型，在校正年龄，吸烟，体重指数（BMI）和腰臀比（WHR）之后，雌激素水平是L期p-0.005期间E-选择素的唯一预测因子​​。雌激素与脂质，载脂蛋白或高半胱氨酸之间无显着相关性。在整个周期的所有阶段中，高半胱氨酸与低密度脂蛋白（LDL）胆固醇和载脂蛋白B之间都存在有趣的显着单变量相关性，在校正了年龄，BMI，WHR和吸烟史的影响后，该相关性仍然存在。所有这些因素的多元回归分析显示，同型半胱氨酸是周期中M期（p = 0.030）和L期（p = 0.023）以及M期LDL胆固醇（p = 0.033）的apo B浓度的重要预测指标。 ）。结论：健康绝经前女性中的性激素可能对E-选择素和同型半胱氨酸代谢的调节作用虽然很小，但具有重要的调节作用。此外，同型半胱氨酸，LDL和载脂蛋白B水平之间的相关性表明，先前在体外显示的同型半胱氨酸对胆固醇合成的诱导在体内可能具有相关性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号