...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International immunopharmacology >The protective effect of vitamin E against prenatal and early postnatal ethanol treatment-induced heart abnormality in rats: A 3-month follow-up study
【24h】

The protective effect of vitamin E against prenatal and early postnatal ethanol treatment-induced heart abnormality in rats: A 3-month follow-up study

机译：维生素E对产前和产后早期乙醇治疗所致大鼠心脏异常的保护作用：3个月的随访研究

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Ethanol consumption during pregnancy is associated with fetal heart malformation. However, the underlying mechanism of prenatal ethanol exposure causing heart malfunction is not well known. The current study examined the effect of prenatal and early postnatal ethanol consumption on heart abnormality resulting from oxidative and inflammatory stress. It was also intended to find out whether vitamin E inhibits the abnormality induced by ethanol in rats' heart tissue. Pregnant Wistar rats received ethanol with/without vitamin E from the seventh day of gestation (GD7) throughout lactation. The proliferation in heart muscle cells and coronary smooth muscle cells, protein carbonyl, IL-6, TNF-alpha, homocysteine levels, also lipid profile in heart and plasma of male pups were measured at the end of lactation (PN 21) and 90 days after birth (PN 90). The results indicated proliferation of heart muscle and coronary smooth muscle cells along with heart structural alteration, protein oxidation, lipid peroxidation, inflammatory reaction, and hyperhomocysteinemia in offspring after 21 and 90 days of birth compared with the controls. Vitamin E treatment significantly decreased cell proliferation and heart structural alteration, compared with the group treated by ethanol alone. Furthermore, it reduced the elevation of protein carbonyl, lipid peroxidation, and increased inflammatory proteins to levels as those of the controls. These findings strongly support the idea that ethanol intake by dams during pregnancy and early postnatal days induces heart abnormality mediated by oxidative stress and inflammatory reactions, and that these effects can be alleviated by using vitamin E as an antioxidant and anti-inflammatory molecule. (C) 2015 Elsevier B.V. All rights reserved.
机译：怀孕期间摄入乙醇与胎儿心脏畸形有关。但是，产前乙醇暴露引起心脏功能障碍的潜在机制尚不清楚。当前的研究检查了产前和产后早期饮酒对氧化应激和炎症应激引起的心脏异常的影响。还旨在确定维生素E是否抑制大鼠心脏组织中乙醇诱导的异常。怀孕的Wistar大鼠从整个哺乳期的妊娠第七天（GD7）开始接受含/不含维生素E的乙醇。在哺乳期结束（PN 21）和90天时测量雄性幼犬的心肌细胞和冠状平滑肌细胞的增殖，羰基蛋白，IL-6，TNF-α，高半胱氨酸水平以及心脏和血浆中的脂质分布出生后（PN 90）。结果表明，与对照组相比，后代在出生后21天和90天后的心肌和冠状平滑肌细胞增殖，以及心脏结构改变，蛋白质氧化，脂质过氧化，炎症反应和高同型半胱氨酸血症。与单独使用乙醇治疗的组相比，维生素E治疗显着降低了细胞增殖和心脏结构改变。此外，它降低了蛋白质羰基的升高，脂质过氧化，并使炎症性蛋白质的水平达到了对照水平。这些发现强烈支持这样的想法，即在怀孕期间和出生后早期，大坝摄入乙醇会诱发由氧化应激和炎症反应介导的心脏异常，并且可以通过使用维生素E作为抗氧化剂和消炎分子来缓解这些影响。 （C）2015 Elsevier B.V.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号