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首页> 外文期刊>International immunopharmacology >Protective effect of Jolkinolide B on LPS-induced mouse acute lung injury
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Protective effect of Jolkinolide B on LPS-induced mouse acute lung injury

机译：Jolkinolide B对LPS诱发的小鼠急性肺损伤的保护作用

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摘要

Jolkinolide B (JB), an ent-abietane diterpenoid, isolated from the dried root of Euphorbia fischeriana, has been reported to have potent anti-tumor and anti-inflammatory activities. However, the effects of JB on acute lung injury (ALI) and underlying molecular mechanisms have not been investigated. The present study aimed to investigate the effect of JB on lipopolysaccharide (LPS)-induced ALI. Male C57BL/6 mice were pretreated with dexamethasone or JB 1 h before intranasal instillation of LPS. The results showed that JB markedly attenuated LPS-induced histological alterations, lung edema, inflammatory cell infiltration, myeloperoxidase (MPO) activity as well as the production of TNE-alpha, IL-6 and IL-1 beta. Furthermore, JB also significantly inhibited LPS-induced the degradation of I kappa B alpha. and phosphorylation of NF-kappa B p65 and MAPK. Therefore, our study provides the first line of evidence that pretreatment of JB has a protective effect on LPS-induced ALI in mice. The anti-inflammatory mechanism of JB may be attributed to its suppression of NF-kappa B and MAPK activation. (C) 2015 Elsevier B.V. All rights reserved.
机译：据报道，从大戟大戟的干燥根中分离得到的对苯二烷二萜类化合物Jolkinolide B（JB）具有有效的抗肿瘤和抗炎活性。但是，尚未研究JB对急性肺损伤（ALI）和潜在分子机制的影响。本研究旨在调查JB对脂多糖（LPS）诱导的ALI的影响。雄性C57BL / 6小鼠在鼻内滴入LPS之前1小时用地塞米松或JB预处理。结果表明，JB明显减轻了LPS诱导的组织学改变，肺水肿，炎性细胞浸润，髓过氧化物酶（MPO）活性以及TNE-α，IL-6和IL-1β的产生。此外，JB还显着抑制LPS诱导的IκB alpha降解。 NFκBp65和MAPK的磷酸化因此，我们的研究提供了第一线证据，表明JB预处理对LPS诱导的小鼠ALI具有保护作用。 JB的抗炎机制可能归因于其抑制NF-κB和MAPK活化。 （C）2015 Elsevier B.V.保留所有权利。

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