Enalapril treatment increases T cell number and promotes polarization towards M1-like macrophages locally in diabetic nephropathy

Cucak Helena; Fink Lisbeth Nielsen; Pedersen Maiken Hojgaard; Rosendahl Alexander

首页> 外文期刊>International immunopharmacology >Enalapril treatment increases T cell number and promotes polarization towards M1-like macrophages locally in diabetic nephropathy

【24h】

Enalapril treatment increases T cell number and promotes polarization towards M1-like macrophages locally in diabetic nephropathy

机译：依那普利治疗可增加T细胞数量并促进糖尿病性肾病中局部向M1样巨噬细胞的极化

获取原文

获取原文并翻译 | 示例

获取外文期刊封面封底 >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Diabetic nephropathy (DN) is a serious complication of longstanding diabetes affecting up to 30% of all diabetes patients and is the main cause of end-stage kidney disease globally. Current standard treatment e.g ACE-inhibitors like enalapril merely offers a delay in the progression leading to DN. Herein, we describe in two preclinical models evidence to local effects on the inflammatory signatures after intervention treatment with enalapril which provides enhanced understanding of the mechanism of ACE inhibitors.

机译：糖尿病肾病（DN）是长期糖尿病的严重并发症，影响了所有糖尿病患者的30％，并且是全球终末期肾脏疾病的主要原因。当前的标准治疗方法，例如依那普利等ACE抑制剂，只能延迟导致DN的进程。在本文中，我们在两个临床前模型中描述了依那普利干预治疗后对炎症信号的局部影响的证据，这增强了对ACE抑制剂机制的了解。

著录项

来源
《International immunopharmacology》 |2015年第1期|共13页
作者
Cucak Helena; Fink Lisbeth Nielsen; Pedersen Maiken Hojgaard; Rosendahl Alexander;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Macrophages; T cells; Diabetic nephropathy; Diabetes; Kidney; Drug treatment;

机译：巨噬细胞;T细胞;糖尿病肾病;糖尿病;肾脏;药物治疗;

相似文献

外文文献
中文文献
专利

1. Enalapril treatment increases T cell number and promotes polarization towards M1-like macrophages locally in diabetic nephropathy [J] . Cucak Helena, Fink Lisbeth Nielsen, Pedersen Maiken Hojgaard, International immunopharmacology . 2015,第1期

机译：依那普利治疗可增加T细胞数量并促进糖尿病性肾病中局部向M1样巨噬细胞的极化
2. Calcitriol Protects Against Renal Tubular Cell Apoptosis by Promoting M2 Macrophages Polarization in Diabetic Nephropathy Rats [J] . Yin-Feng Guo, Zhi-Xia Song, Min Zhou, Hong Kong Journal of Nephrology . 2015,第2期

机译：骨化三醇通过促进糖尿病性肾病大鼠的M2巨噬细胞极化来防止肾小管细胞凋亡。
3. In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells [J] . Gaurav Luthria, Ran Li, Stephanie Wang, Nature Communications . 2020,第1期

机译：体内显微镜显示巨噬细胞极化局部促进迁移癌细胞中的相干微管动态
4. MNPs Promote the M2 Subtype towards M1-like Subtype Macrophages and Microglias [C] . Yingze Li, Chang chen, Yu Cheng The 8th International Conference on Magneto- Science（第八届国际磁科学会议）论文集 . -1

机译：Mnps促进M2亚型朝向M1样亚型巨噬细胞和微胶质型
5. Inhibition of inflammatory cytokines - potential new treatment for diabetic nephropathy [D] . Correia, Amanda R. 2015

机译：抑制炎症细胞因子 - 糖尿病肾病的潜在新待遇
6. In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells [O] . Gaurav Luthria, Ran Li, Stephanie Wang, -1

机译：体内显微镜显示巨噬细胞极化局部促进迁移的癌细胞中相干的微管动力学
7. Enalapril treatment increases T cell number and promotes polarization towards M1-like macrophages locally in diabetic nephropathy [O] . Cucak Helena, Nielsen Fink Lisbeth, Højgaard Pedersen Maiken, 2015

机译：依那普利治疗可增加T细胞数量并促进糖尿病性肾病中局部向M1样巨噬细胞的极化

Enalapril treatment increases T cell number and promotes polarization towards M1-like macrophages locally in diabetic nephropathy

摘要

著录项

相似文献

相关主题

期刊订阅