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首页> 外文期刊>International immunopharmacology >Anti-IL-23 antibody blockade of IL-23/IL-17 pathway attenuates airway obliteration in rat orthotopic tracheal transplantation.
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Anti-IL-23 antibody blockade of IL-23/IL-17 pathway attenuates airway obliteration in rat orthotopic tracheal transplantation.

机译：IL-23 / IL-17途径的抗IL-23抗体阻滞减弱了大鼠原位气管移植中的气道闭塞。

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摘要

Obliterative bronchiolitis (OB) has been a major obstacle to long-term allograft survival after lung transplantation, and the underlying mechanism is not well understood. As IL-23/IL-17 pathway has been shown to play important roles in airway inflammation, in this study we have investigated the role of IL-23/IL-17 pathway in acute and chronic airway allograft rejection. We used a rat OB model in orthotopic tracheal transplantation, and investigated the effects of anti-IL-23 blockade antibody on acute and chronic airway allograft rejection. Anti-IL-23 antibody impaired the function of IL-23 in inducing IL-17 production. The rats that received allografts and treated with anti-IL-23 antibody showed significantly less symptom of airway obliteration and chronic transplant rejection compared with control rats which received physiological saline or IgG antibody. Taken together, our results suggest that anti-IL-23 antibody is effective in protecting allograft rejection and the development of chronic OB in allo-tracheal transplantation. These findings may have implications for new therapies to prevent OB and allograft rejection in human lung transplantation.
机译：闭塞性细支气管炎（OB）一直是肺移植后同种异体移植物长期存活的主要障碍，其潜在机制尚不清楚。由于已显示IL-23 / IL-17途径在气道炎症中起重要作用，因此在这项研究中，我们研究了IL-23 / IL-17途径在急性和慢性气道异体移植排斥中的作用。我们在原位气管移植中使用了大鼠OB模型，并研究了抗IL-23阻断抗体对急性和慢性气道异体移植排斥的影响。抗IL-23抗体损害了IL-23在诱导IL-17产生中的功能。与接受生理盐水或IgG抗体的对照组相比，接受同种异体移植并用抗IL-23抗体治疗的大鼠表现出明显更少的气道闭塞和慢性移植排斥症状。综上所述，我们的结果表明抗IL-23抗体可有效保护同种异体气管移植中的同种异体移植排斥和慢性OB的发展。这些发现可能对预防人肺移植中的OB和同种异体移植排斥的新疗法有影响。

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