Regulation of adaptive immunity by the NLRP3 inflammasome.

Chen M; Wang H; Chen W; Meng G

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Regulation of adaptive immunity by the NLRP3 inflammasome.

机译：NLRP3炎性小体对适应性免疫的调节。

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It is well known that the innate immune system can induce and regulate the development of adaptive immunity. The NLRP3 inflammasome is a multiprotein complex that controls the caspase-1 activation step that is a pre-requisite for the maturation of interleukin (IL)-1beta and IL-18. Recent findings showed that the NLRP3 inflammasome not only is an innate responder to pathogenic and danger signals, but also can affect the adaptive immune response. Here we review the role of NLRP3 inflammasome in regulating adaptive immunity.

机译：众所周知，先天免疫系统可以诱导和调节适应性免疫的发展。 NLRP3炎性小体是一种多蛋白复合物，可控制caspase-1激活步骤，这是白介素（IL）-1beta和IL-18成熟的先决条件。最近的发现表明，NLRP3炎性小体不仅是对致病和危险信号的先天反应者，而且还可以影响适应性免疫反应。在这里，我们回顾了NLRP3炎性小体在调节适应性免疫中的作用。

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《International immunopharmacology》 |2011年第5期|共6页
作者
Chen M; Wang H; Chen W; Meng G;
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正文语种 eng
中图分类药理学;
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3. Regulation of adaptive immunity by the NLRP3 inflammasome. [J] . Chen M, Wang H, Chen W, International immunopharmacology . 2011,第5期

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Regulation of adaptive immunity by the NLRP3 inflammasome.

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