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首页> 外文期刊>International Journal for Parasitology >Trypanosoma vivax displays a clonal population structure.
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Trypanosoma vivax displays a clonal population structure.

机译：间日锥虫显示出克隆的种群结构。

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African animal trypanosomiasis, or Nagana, is a debilitating and economically costly disease with a major impact on animal health in sub-Saharan Africa. Trypanosoma vivax, one of the principal trypanosome species responsible for the disease, infects a wide host range including cattle, goats, horses and donkeys and is transmitted both cyclically by tsetse flies and mechanically by other biting flies, resulting in a distribution covering large swathes of South America and much of sub-Saharan Africa. While there is evidence for mating in some of the related trypanosome species, Trypanosoma brucei, Trypanosoma congolense and Trypanosoma cruzi, very little work has been carried out to examine this question in T. vivax. Understanding whether mating occurs in T. vivax will provide insight into the dynamics of trait inheritance, for example the spread of drug resistance, as well as examining the origins of meiosis in the order Kinetoplastida. With this in mind we have identified orthologues of eight core meiotic genes within the genome, the presence of which imply that the potential for mating exists in this species. In order to address whether mating occurs, we have investigated a sympatric field population of T. vivax collected from livestock in The Gambia, using microsatellite markers developed for this species. Our analysis has identified a clonal population structure showing significant linkage disequilibrium, homozygote deficits and disagreement with Hardy-Weinberg predictions at six microsatellite loci, indicative of a lack of mating in this population of T. vivax.
机译：非洲动物锥虫病（Nagana）是一种使人衰弱且经济上昂贵的疾病，对撒哈拉以南非洲的动物健康具有重大影响。间日锥虫是造成该病的主要锥虫物种之一，感染了包括牛，山羊，马和驴在内的多种寄主，并由采采蝇和其他咬蝇以周期性方式传播，从而导致大面积分布。南美和撒哈拉以南非洲大部分地区。虽然有证据表明某些相关的锥虫物种布鲁氏锥虫，锥虫锥虫和克氏锥虫可以交配，但很少开展工作来研究间日疟原虫的这一问题。了解是否在间日疟原虫中发生交配，将有助于深入了解性状遗传的动态，例如耐药性的传播，并按照动生殖体的顺序检查减数分裂的起源。考虑到这一点，我们确定了基因组中八个核心减数分裂基因的直向同源物，其存在暗示该物种存在交配的潜力。为了解决是否发生交配，我们使用为该物种开发的微卫星标记，调查了从冈比亚家畜收集的间日疟原虫的同居田间种群。我们的分析确定了一个克隆种群结构，该克隆结构在六个微卫星基因座上显示出显着的连锁不平衡，纯合子缺陷和与Hardy-Weinberg的预测不一致，表明该间日疟原虫种群缺乏交配。

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