...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International heart journal >Temporal changes in plasma brain natriuretic peptide levels during exercise stress-echocardiography in patients with dilated cardiomyopathy: Relationship to left ventricular contractile reserve
【24h】

Temporal changes in plasma brain natriuretic peptide levels during exercise stress-echocardiography in patients with dilated cardiomyopathy: Relationship to left ventricular contractile reserve

机译：扩张型心肌病患者运动应激超声心动图期间血浆脑利钠肽水平的时空变化：与左心室收缩储备的关系

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of this study was to evaluate temporal changes in brain natriuretic petide (BNP) levels during exercise stress-echocardiography in patients with dilated cardiomyopathy with respect to the left ventricular contractile reserve. We studied 55 consecutive patients with dilated cardiomyopathy (mean age, 55 ± 10 years, 49 (89.1%) male). All patients underwent exercise stress-echocardiography on a treadmill using the modified Bruce protocol. Contractile reserve was assessed by measuring changes in the wall motion score index (ΔWMSI) at rest and and at peak exercise. Levels of BNP were measured at rest, in the first minute, and after 20 minutes following termination of the stress test. Thirty-six patients had preserved left ventricular contractile reserve and 19 patients did not. Patients with preserved left ventricular contractile reserve showed a continuous rise in BNP levels from baseline to peak exercise and to 20 minutes following exertion (83.95 ± 108.51 versus 105.89 ± 116.00 versus 110.95 ± 119.70 ng/L, P < 0.001, respectively). On the other hand, patients without preserved left ventricular contractile reserve showed a decline in BNP levels at peak exercise as compared to baseline (335.49 ± 693.11 versus 320.08 ± 562.60 P = 0.031). ΔBNP was positively correlated with preserved contractile reserve (r = 0.46, P = 0.03) and lower NYHA class (r = -0.65, P = 0.001) in patients in whom baseline LVEF was lower than 20%. Multivariate analysis identified only WMSI at rest (beta -3.365, P = 0.008, 95 CI 0.03 to 0.411) as an independent predictor of left ventricular contractile reserve.The increase in BNP levels during exercise stress-echocardiography is associated with preserved left ventricular contractile reserve in patients with dilated cardiomyopathy.
机译：这项研究的目的是评估运动型心电图检查对扩张型心肌病患者左心室收缩储备在脑钠尿肽（BNP）水平的时间变化。我们研究了55位连续的扩张型心肌病患者（平均年龄，55±10岁，男性49位（89.1％））。所有患者均使用改良的Bruce方案在跑步机上进行了运动压力超声心动图检查。通过测量静止和高峰运动时壁运动得分指数（ΔWMSI）的变化来评估收缩储备。压力测试终止后，在休息时，第一分钟和20分钟后测量BNP水平。三十六例患者保留了左心室收缩储备，而十九例患者没有。保留左心室收缩储备的患者从基线运动到峰值运动以及运动后20分钟BNP水平持续升高（分别为83.95±108.51 ng对105.89±116.00 vs 110.95±119.70 ng / L，P <0.001）。另一方面，与基线相比，没有保留左心室收缩储备的患者在峰值运动时BNP水平下降（335.49±693.11与320.08±562.60 P = 0.031）。在基线LVEF低于20％的患者中，ΔBNP与保留的收缩储备（r = 0.46，P = 0.03）和较低的NYHA分级（r = -0.65，P = 0.001）呈正相关。多变量分析仅将静止时的WMSI（β-3.365，P = 0.008，95 CI 0.03至0.411）作为左心室收缩储备的独立预测因子。运动负荷超声心动图期间BNP水平的升高与左心室收缩储备的保留在扩张型心肌病患者中。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号