The heat shock protein 90 of Eimeria tenella is essential for invasion of host cell and schizont growth

Peroval Marylene

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The heat shock protein 90 of Eimeria tenella is essential for invasion of host cell and schizont growth

机译：艾美耳球虫的热激蛋白90对于入侵宿主细胞和裂殖体生长至关重要

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The 90-kDa heat shock proteins (Hsp90) are important for stress tolerance, for newly synthesised protein folding and for the growth of various organisms. Participation of Hsp90 in the development of Apicomplexa, notably in Plasmodium falciparum and Toxoplasma gondii, has been proven. In this work, the importance of Hsp90 for Eimeria tenella, which is responsible for avian caecal coccidiosis, was studied. Our results show that E. tenella Hsp90 (EtHsp90) expression increases during infection. Immunofluorescence microscopy studies reveal a dispersed localisation of EtHsp90 during the first schizogony. Moreover, EtHsp90 is secreted by sporozoites as early as 5 min after addition of FCS in a temperature-dependent manner. By using staurosporine, we invalidated the hypothesis that EtHsp90 might be a micronemal protein. Then, EtHsp90 was detected in a parasitophorous vacuole membrane. This result suggests the importance of EtHsp90 for intracellular growth of the parasite. Inhibition of EtHsp90 function using specific antibodies and geldanamicin attenuates the capacity of E. tenella to invade and grow in the host cell.

机译：90 kDa热激蛋白（Hsp90）对于胁迫耐受性，新合成的蛋白折叠以及各种生物的生长都很重要。 Hsp90参与了复杂的蚜虫的发展，特别是在恶性疟原虫和弓形体中的参与。在这项工作中，研究了Hsp90对负责禽盲肠球虫病的艾美尔球虫的重要性。我们的结果显示，在感染过程中，大肠杆菌EspHsp90（EtHsp90）表达增加。免疫荧光显微镜研究揭示了在第一次精神分裂期间EtHsp90的分散定位。此外，EtHsp90早在添加FCS后5分钟就以温度依赖性方式由子孢子分泌。通过使用星形孢菌素，我们使EtHsp90可能是微nemalmal蛋白的假设无效。然后，在寄生的液泡膜中检测到EtHsp90。该结果表明EtHsp90对于寄生虫的细胞内生长的重要性。使用特异性抗体和geldanamicin抑制EtHsp90功能会减弱大肠杆菌在宿主细胞中侵袭和生长的能力。

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《International Journal for Parasitology》 |2006年第11期|共11页
作者
Peroval Marylene;
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正文语种 eng
中图分类寄生动物、寄生虫学;寄生虫病;
关键词
Eimeria tenella; 90-kDa heat shock protein; Secretion; Geldanamicin;

机译：艾美耳球虫;90 kDa热激蛋白;分泌;吉达那霉素;

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1. The heat shock protein 90 of Eimeria tenella is essential for invasion of host cell and schizont growth [J] . Peroval Marylene International Journal for Parasitology . 2006,第10a11期

机译：艾美耳球虫的热激蛋白90对于入侵宿主细胞和裂殖体生长至关重要
2. The heat shock protein 90 of Eimeria tenella is essential for invasion of host cell and schizont growth. [J] . Peroval M, Pery P, Labbe M International Journal for Parasitology . 2006,第10a11期

机译：艾美耳球虫的热激蛋白90对于入侵宿主细胞和裂殖体生长至关重要。
3. The heat shock protein 90 of Toxoplasma gondii is essential for invasion of host cells and tachyzoite growth [J] . Hongchao Sun, Xunhui Zhuo, Xianfeng Zhao, Parasite . 2017,第1期

机译：弓形虫的热激蛋白90对宿主细胞的侵袭和速殖子的生长至关重要
4. Identification and Characterization of Secreted Proteins in Eimeria tenella [C] . Intan Azlinda Ramlee, Mohd Firdaus-Raih, Kiew-Lian Wan UKM FST Postgraduate Colloquium . 2015

机译：eimeria tenella分泌蛋白质的鉴定与表征
5. The expression of heat shock protein 70, heat shock protein 90 and heat shock factor 1 within the bovine midcycle corpus luteum after stimulation with temperature in vitro and PGF2alpha in vitro and in vivo. [D] . Kopka, Melissa N. 2006

机译：热激蛋白70，热激蛋白90和热激因子1在体外温度和体外及体内PGF2α刺激后在牛黄体中体中的表达。
6. The heat shock protein 90 of Toxoplasma gondii is essential for invasion of host cells and tachyzoite growth [O] . Hongchao Sun, Xunhui Zhuo, Xianfeng Zhao, 2017

机译：弓形虫的热休克蛋白90对宿主细胞的侵袭和速殖子的生长至关重要
7. The heat shock protein 90 of Toxoplasma gondii is essential for invasion of host cells and tachyzoite growth [O] . Hongchao Sun, Xunhui Zhuo, Xianfeng Zhao, 2017

机译：弓形虫的热休克蛋白90对于宿主细胞和Tachyzoite生长至关重要

The heat shock protein 90 of Eimeria tenella is essential for invasion of host cell and schizont growth

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