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首页> 外文期刊>British journal of ophthalmology >One-year follow-up of macular ganglion cell layer and peripapillary retinal nerve fibre layer thickness changes after panretinal photocoagulation
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One-year follow-up of macular ganglion cell layer and peripapillary retinal nerve fibre layer thickness changes after panretinal photocoagulation

机译：全视网膜光凝后黄斑神经节细胞层和乳头周围视网膜神经纤维层厚度变化的一年随访

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Background/aims To assess the changes of ganglion cell-inner plexiform layer (GCIPL) thickness, retinal nerve fibre layer (RNFL) thickness, and central subfield thickness (CST) after panretinal photocoagulation (PRP) in diabetic retinopathy for 1 year. Methods This prospective, interventional case series study examined 35 patients (35 eyes) undergoing PRP, who were diagnosed with severe non-proliferative diabetic retinopathy to non-high-risk proliferative diabetic retinopathy without macular oedema. Macular GCIPL thickness, CST, and peripapillary RNFL thickness were measured by spectral-domain optical coherence tomography at baseline, and then at 1, 3, 6, 9 and 12 months after PRP. Results Macular GCIPL and peripapillary RNFL (average and all sections) thickness at each follow-up increased significantly from the baseline (p≤0.001, respectively). The average, superior and inferior RNFL thickness at 12 months after PRP decreased significantly compared to the 1-month post-PRP (p=0.007, p=0.028 and p=0.025). The average GCIPL and temporal RNFL thickness showed a significant correlation at each followup (p≤0.001, respectively). CST at each follow-up increased significantly from the baseline ( p≤0.001, respectively). Conclusions The macular GCIPL and peripapillary RNFL thickness increased throughout the 1-year post- PRP. Furthermore, the macular GCIPL and temporal RNFL thickness showed a significant correlation throughout the 1 year of follow-up.
机译：背景/目的评估糖尿病性视网膜病变全视网膜光凝（PRP）1年后神经节细胞内丛状层（GCIPL）厚度，视网膜神经纤维层（RNFL）厚度和中央子区厚度（CST）的变化。方法这项前瞻性，干预性病例系列研究检查了35例接受PRP的患者（35眼），这些患者被诊断为严重的非增生性糖尿病视网膜病变为非高风险，无黄斑水肿的增生性糖尿病视网膜病变。黄斑GCIPL厚度，CST和乳头周围RNFL厚度在基线，然后在PRP后的1、3、6、9和12个月通过光谱域光学相干断层扫描进行测量。结果每次随访时黄斑GCIPL和乳头周围RNFL（平均和所有切片）厚度均较基线显着增加（分别为p≤0.001）。与PRP术后1个月相比，PRP术后12个月的平均，上，下RNFL厚度显着降低（p = 0.007，p = 0.028和p = 0.025）。在每次随访中，平均GCIPL和颞RNFL厚度均显示出显着相关性（分别为p≤0.001）。每次随访的CST均较基线显着增加（分别为p≤0.001）。结论在PRP术后1年中，黄斑区GCIPL和乳头周围RNFL厚度增加。此外，在整个随访的1年中，黄斑GCIPL和颞RNFL厚度显示出显着的相关性。

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