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首页> 外文期刊>British journal of ophthalmology >Vertical or asymmetric nystagmus need not imply neurological disease.
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Vertical or asymmetric nystagmus need not imply neurological disease.

机译：垂直或不对称的眼球震颤不一定意味着神经系统疾病。

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摘要

AIM: To indicate that congenital idiopathic nystagmus (CIN) and sensory defect nystagmus (SDN) can be vertical or asymmetric in some children. METHODS: Of 276 children presenting with nystagmus for electrophysiological testing, 14 were identified as having CIN or SDN, yet had a nystagmus which was either vertical (n=11) or horizontal asymmetric (n=3). Flash electroretinograms and flash and pattern visual evoked potentials (VEPs) were recorded in all patients. Eye movement assessment, including horizontal optokinetic nystagmus (OKN) testing, was carried out in 11/14 patients. RESULTS: Eight patients (seven with vertical, one with asymmetric horizontal nystagmus) had congenital cone dysfunction. One patient with vertical and another with asymmetric nystagmus had cone-rod dystrophy. One patient with vertical upbeat had congenital stationary night blindness. Two patients (one downbeat, one upbeat nystagmus) had normal electrophysiological, clinical, and brain magnetic resonance imaging findings and were classified as having CIN. One patient with asymmetric nystagmus showed electrophysiological and clinical findings associated with albinism. Horizontal OKN was present in 80% of patients tested, including the three cases with horizontal asymmetric nystagmus. This is atypical in both CIN and SDN, where the OKN is usually absent. CONCLUSIONS: Vertical and asymmetric nystagmus are most commonly associated with serious intracranial pathology and its presence is an indication for neuroimaging studies. However, such nystagmus can occur in children with retinal disease, albinism, and in cases with CIN. These findings stress the importance of non-invasive VEP/ERG testing in all cases of typical and also atypical nystagmus.
机译：目的：表明某些儿童先天性特发性眼球震颤（CIN）和感觉缺陷性眼球震颤（SDN）可能是垂直的或不对称的。方法：在276名患有眼球震颤进行电生理检查的儿童中，有14名被确认患有CIN或SDN，但其眼球震颤呈垂直（n = 11）或水平不对称（n = 3）。记录所有患者的闪光视网膜电图以及闪光和图案视觉诱发电位（VEP）。在11/14例患者中进行了眼动评估，包括水平视动性眼球震颤（OKN）测试。结果：8例患者（7例为垂直型，1例为不对称水平眼球震颤）患有先天性视锥功能障碍。一名患有垂直疾病的患者，另一名患有不对称眼球震颤的患者患有锥体棒型营养不良。一名垂直乐观的患者患有先天性静止性夜盲症。两名患者（一名情绪低落，一名情绪异常眼球震颤）具有正常的电生理，临床和脑磁共振成像表现，并被分类为CIN。一名患有不对称眼球震颤的患者表现出与白化病相关的电生理和临床发现。 80％的患者接受了水平OKN，包括三例水平不对称眼球震颤。这在CIN和SDN中都是非典型的，而OKN通常不存在。结论：垂直和不对称的眼球震颤最常与严重的颅内病理相关，其存在是神经影像学研究的指标。但是，这种眼球震颤可能发生在患有视网膜疾病，白化病的儿童以及患有CIN的儿童中。这些发现强调了在所有典型和非典型眼球震颤病例中非侵入性VEP / ERG检测的重要性。

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