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首页> 外文期刊>International journal of antimicrobial agents >Immunomodulating effect of antimicrobial agents on cytokine production by human polymorphonuclear neutrophils
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Immunomodulating effect of antimicrobial agents on cytokine production by human polymorphonuclear neutrophils

机译：抗菌剂对人多形核中性粒细胞产生细胞因子的免疫调节作用

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摘要

It has been previously demonstrated that some antimicrobial agents enhance activities of human polymorphonuclear neutrophils (PMNs). The effect on the release of cytokines in an inflammatory context from PMNs by these antibiotics was evaluated. We studied the effect of the release of some cytokines by human PMNs RT-PCR analysis on a clinical strain of Klebsiella pneumoniae by comparing the effect with that observed in the presence of co-amoxiclav, sanfetrinem, clarithromycin, prulifloxacin and tobramycin. All the drugs tested were capable of modulating PMN synthesis in vitro of pro-inflammatory cytokines IL-8, IL-1beta, TNF-alpha. and IL-6, but not that of anti-inflammatory cytokine IL-10. The degree of their stimulatory or inhibitory potency varied with the cytokine examined. (C) 2003 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved. [References: 20]
机译：先前已证明某些抗菌剂可增强人多形核中性粒细胞（PMN）的活性。评估了这些抗生素对炎性环境中PMN释放细胞因子的影响。我们将人PMNs逆转录-聚合酶链反应（RTN-PCR）分析对肺炎克雷伯菌的临床菌株研究了某些细胞因子释放的作用，方法是将其与在存在共阿莫西拉夫，桑非特林，克拉霉素，普鲁沙星和妥布霉素的情况下观察到的作用进行比较。所有测试的药物均能够在体外调节促炎细胞因子IL-8，IL-1beta，TNF-α的PMN合成。和IL-6，但不包括抗炎细胞因子IL-10。它们的刺激或抑制效力的程度随所检查的细胞因子而变化。 （C）2003年Elsevier B.V.和国际化学疗法学会。版权所有。 [参考：20]

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